Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells.

Antineoplastic Combined Chemotherapy Protocols / pharmacology Apigenin / pharmacology Apoptosis Colorectal Neoplasms / drug therapy Drug Resistance, Neoplasm Drug Synergism Fluorouracil / pharmacology Humans Thymidylate Synthase / genetics
Apigenin Chemoresistance Colon cancer P53 Thymidylate synthase

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
11 2021
Historique:
received: 13 08 2021
revised: 05 09 2021
accepted: 19 09 2021
pubmed: 26 9 2021
medline: 1 12 2021
entrez: 25 9 2021
Statut: ppublish

Résumé

Although effective drugs have been developed, including 5-fluorouracil (5-FU), advanced colorectal cancer (CRC) shows low therapeutic sensitivity resulting from the development of 5-FU resistance. Thymidylate synthase (TS) is a target protein of 5-FU, and elevated TS lowers the 5-FU sensitivity of CRC cells. Here, we tested the efficacy of several candidate phytochemicals against human CRC-derived HCT116 cells expressing wild-type tumor suppressor protein P53 and HT29 cells expressing mutant P53. Among them, we found that apigenin enhanced the inhibitory effect of 5-FU on cell viability. In addition, apigenin inhibited the upregulation of TS induced by 5-FU. Apigenin also potentiated 5-FU-induced apoptosis of HCT116 cells and enhanced cell cycle disruption. Furthermore, apigenin increased reactive oxygen species production, intracellular and intramitochondrial Ca

Identifiants

DOI: 10.1016/j.redox.2021.102144 PMID: 34562873 PMC: PMC8476449
pubmed: 34562873
pii: S2213-2317(21)00303-7
doi: 10.1016/j.redox.2021.102144
pmc: PMC8476449
pii:
doi:

Substances chimiques

Apigenin 7V515PI7F6
Thymidylate Synthase EC 2.1.1.45
Fluorouracil U3P01618RT

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102144

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Changwon Yang (C)

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.

Jisoo Song (J)

Department of Food and Nutrition, College of Science and Technology, Kookmin University, Seoul, 02707, Republic of Korea.

Sunjae Hwang (S)

School of Mechanical Engineering, Kookmin University, Seoul, 02707, Republic of Korea.

Jungil Choi (J)

School of Mechanical Engineering, Kookmin University, Seoul, 02707, Republic of Korea.

Gwonhwa Song (G)

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea. Electronic address: ghsong@korea.ac.kr.

Whasun Lim (W)

Department of Food and Nutrition, College of Science and Technology, Kookmin University, Seoul, 02707, Republic of Korea. Electronic address: wlim@kookmin.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Protocoles de polychimiothérapie antinéoplasique › Apigenin enhances apoptosis induction by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavones › Apigénine › Apigenin enhances apoptosis induction by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Apigenin enhances apoptosis induction by...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Apigenin enhances apoptosis induction by...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Apigenin enhances apoptosis induction by...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Synergie des médicaments › Apigenin enhances apoptosis induction by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Uracile › Fluorouracil › Apigenin enhances apoptosis induction by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Apigenin enhances apoptosis induction by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Thymidylate synthase › Apigenin enhances apoptosis induction by...