Autophagy and the hallmarks of aging.
Aging
Chaperones
Lysosomes
Organelle turnover
Proteolysis
Proteostasis
Journal
Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
30
06
2021
revised:
12
09
2021
accepted:
20
09
2021
pubmed:
27
9
2021
medline:
29
1
2022
entrez:
26
9
2021
Statut:
ppublish
Résumé
Autophagy, an essential cellular process that mediates degradation of proteins and organelles in lysosomes, has been tightly linked to cellular quality control for its role as part of the proteostasis network. The current interest in identifying the cellular and molecular determinants of aging, has highlighted the important contribution of malfunctioning of autophagy with age to the loss of proteostasis that characterizes all old organisms. However, the diversity of cellular functions of the different types of autophagy and the often reciprocal interactions of autophagy with other determinants of aging, is placing autophagy at the center of the aging process. In this work, we summarize evidence for the contribution of autophagy to health- and lifespan and provide examples of the bidirectional interplay between autophagic pathways and several of the so-called hallmarks of aging. This central role of autophagy in aging, and the dependence on autophagy of many geroprotective interventions, has motivated a search for direct modulators of autophagy that could be used to slow aging and extend healthspan. Here, we review some of those ongoing therapeutic efforts and comment on the potential of targeting autophagy in aging.
Identifiants
pubmed: 34563704
pii: S1568-1637(21)00215-4
doi: 10.1016/j.arr.2021.101468
pmc: PMC8616816
mid: NIHMS1742991
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101468Subventions
Organisme : NINDS NIH HHS
ID : U54 NS100717
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG021904
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK041296
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124308
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG021904
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054108
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG038072
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031782
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098408
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG017617
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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