FHR-5 Serum Levels and
Adolescent
Adult
Alleles
Antigen-Antibody Complex
/ immunology
Biomarkers
Case-Control Studies
Complement Activation
Complement C3
/ immunology
Complement System Proteins
/ genetics
Disease Management
Disease Susceptibility
Enzyme-Linked Immunosorbent Assay
Female
Genetic Predisposition to Disease
Genetic Variation
Glomerulonephritis, Membranoproliferative
/ blood
Humans
Kidney Function Tests
Male
Polymorphism, Single Nucleotide
Prognosis
ROC Curve
Symptom Assessment
Young Adult
C3 glomerulonephritis (C3GN)
C3 glomerulopathy
dense deposit disease (DDD)
immune complex-mediated glomerulonephritis
membranoproliferative glomerulonephritis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
06
2021
accepted:
11
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
22
12
2021
Statut:
epublish
Résumé
Factor H-related protein 5 (FHR-5) is a member of the complement Factor H protein family. Due to the homology to Factor H, the main complement regulator of the alternative pathway, it may also be implicated in the pathomechanism of kidney diseases where Factor H and alternative pathway dysregulation play a role. Here, we report the first observational study on A total of 120 patients with a histologically proven diagnosis of IC-MPGN/C3G were enrolled in the study. FHR-5 serum levels were measured in ELISA, the Eight exonic Our observations raise the possibility that the FHR-5 protein plays a fine-tuning role in the pathogenesis of IC-MPGN/C3G.
Sections du résumé
Background
Factor H-related protein 5 (FHR-5) is a member of the complement Factor H protein family. Due to the homology to Factor H, the main complement regulator of the alternative pathway, it may also be implicated in the pathomechanism of kidney diseases where Factor H and alternative pathway dysregulation play a role. Here, we report the first observational study on
Methods
A total of 120 patients with a histologically proven diagnosis of IC-MPGN/C3G were enrolled in the study. FHR-5 serum levels were measured in ELISA, the
Results
Eight exonic
Conclusions
Our observations raise the possibility that the FHR-5 protein plays a fine-tuning role in the pathogenesis of IC-MPGN/C3G.
Identifiants
pubmed: 34566977
doi: 10.3389/fimmu.2021.720183
pmc: PMC8461307
doi:
Substances chimiques
Antigen-Antibody Complex
0
Biomarkers
0
CFHR5 protein, human
0
Complement C3
0
Complement System Proteins
9007-36-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
720183Informations de copyright
Copyright © 2021 Garam, Cserhalmi, Prohászka, Szilágyi, Veszeli, Szabó, Uzonyi, Iliás, Aigner, Schmidt, Gaggl, Sunder-Plassmann, Bajcsi, Brunner, Dumfarth, Cejka, Flaschberger, Flögelova, Haris, Hartmann, Heilos, Mueller, Rusai, Arbeiter, Hofer, Jakab, Sinkó, Szigeti, Bereczki, Janko, Kelen, Reusz, Szabó, Klenk, Kóbor, Kojc, Knechtelsdorfer, Laganovic, Lungu, Meglic, Rus, Kersnik Levart, Macioniene, Miglinas, Pawłowska, Stompór, Podracka, Rudnicki, Mayer, Rysava, Reiterova, Saraga, Seeman, Zieg, Sládková, Stajic, Szabó, Capitanescu, Stancu, Tisljar, Galesic, Tislér, Vainumäe, Windpessl, Zaoral, Zlatanova, Józsi and Csuka.
Déclaration de conflit d'intérêts
Author VJ was employed by company Medimpax. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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