Improved COVID-19 Outcomes following Statin Therapy: An Updated Systematic Review and Meta-analysis.
COVID-19
/ mortality
Cause of Death
/ trends
Hospitalization
/ statistics & numerical data
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ pharmacology
Intensive Care Units
Intubation, Intratracheal
/ statistics & numerical data
Models, Statistical
Observational Studies as Topic
Randomized Controlled Trials as Topic
Survival Analysis
Treatment Outcome
COVID-19 Drug Treatment
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
06
2021
accepted:
03
09
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
2
10
2021
Statut:
epublish
Résumé
Although vaccine rollout for COVID-19 has been effective in some countries, there is still an urgent need to reduce disease transmission and severity. We recently carried out a meta-analysis and found that pre- and in-hospital use of statins may improve COVID-19 mortality outcomes. Here, we provide an updated meta-analysis in an attempt to validate these results and increase the statistical power of these potentially important findings. The meta-analysis investigated the effect of observational and randomized clinical studies on intensive care unit (ICU) admission, tracheal intubation, and death outcomes in COVID-19 cases involving statin treatment, by searching the scientific literature up to April 23, 2021. Statistical analysis and random effect modeling were performed to assess the combined effects of the updated and previous findings on the outcome measures. Taken together, this updated meta-analysis extends and confirms the findings of our previous study, suggesting that in-hospital statin use leads to significant reduction of all-cause mortality in COVID-19 cases. Considering these results, statin therapy during hospitalization, while indicated, should be recommended.
Sections du résumé
BACKGROUND
BACKGROUND
Although vaccine rollout for COVID-19 has been effective in some countries, there is still an urgent need to reduce disease transmission and severity. We recently carried out a meta-analysis and found that pre- and in-hospital use of statins may improve COVID-19 mortality outcomes. Here, we provide an updated meta-analysis in an attempt to validate these results and increase the statistical power of these potentially important findings.
METHODS
METHODS
The meta-analysis investigated the effect of observational and randomized clinical studies on intensive care unit (ICU) admission, tracheal intubation, and death outcomes in COVID-19 cases involving statin treatment, by searching the scientific literature up to April 23, 2021. Statistical analysis and random effect modeling were performed to assess the combined effects of the updated and previous findings on the outcome measures.
CONCLUSION
CONCLUSIONS
Taken together, this updated meta-analysis extends and confirms the findings of our previous study, suggesting that in-hospital statin use leads to significant reduction of all-cause mortality in COVID-19 cases. Considering these results, statin therapy during hospitalization, while indicated, should be recommended.
Identifiants
pubmed: 34568488
doi: 10.1155/2021/1901772
pmc: PMC8463212
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1901772Informations de copyright
Copyright © 2021 Amir Vahedian-Azimi et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
J Community Health. 2020 Dec;45(6):1270-1282
pubmed: 32918645
Stat Med. 1996 Mar 30;15(6):619-29
pubmed: 8731004
Sci Rep. 2020 Oct 30;10(1):18716
pubmed: 33127965
BMJ Open. 2020 Dec 4;10(12):e044421
pubmed: 33277291
Med Princ Pract. 2021;30(2):185-192
pubmed: 33197912
Heart. 2020 Oct;106(19):1503-1511
pubmed: 32737124
Eur Heart J. 2020 May 14;41(19):1821-1829
pubmed: 32383763
BMJ Open Diabetes Res Care. 2021 Jan;9(1):
pubmed: 33408084
BMJ Open. 2021 Apr 19;11(4):e045077
pubmed: 33875444
Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1662-1670
pubmed: 33838992
Pathogens. 2020 Sep 17;9(9):
pubmed: 32957539
Cell Metab. 2020 Aug 4;32(2):176-187.e4
pubmed: 32592657
J Am Coll Cardiol. 2020 Aug 4;76(5):533-546
pubmed: 32517963
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Transl Med Commun. 2021;6(1):3
pubmed: 33521322
J Am Med Dir Assoc. 2020 Jul;21(7):909-914.e2
pubmed: 32674818
J Pers Med. 2021 Feb 10;11(2):
pubmed: 33578937
Intern Emerg Med. 2020 Nov;15(8):1573-1576
pubmed: 33011928
J Health Econ Outcomes Res. 2020 Sep 29;7(2):165-174
pubmed: 33043063
JAMA Intern Med. 2020 Oct 1;180(10):1345-1355
pubmed: 32667669
Eur Heart J Cardiovasc Pharmacother. 2022 Feb 16;8(2):157-164
pubmed: 33135047
Crit Care. 2020 Jul 14;24(1):429
pubmed: 32664990
Biometrics. 1994 Dec;50(4):1088-101
pubmed: 7786990
Dtsch Arztebl Int. 2020 Apr 17;117(16):271-278
pubmed: 32519944
Am J Trop Med Hyg. 2020 Jul;103(1):69-72
pubmed: 32446312
J Clin Lipidol. 2021 Jan-Feb;15(1):68-78
pubmed: 33390341
EClinicalMedicine. 2021 Mar;33:100765
pubmed: 33655204
Arch Med Sci. 2020 Apr 25;16(3):490-496
pubmed: 32399094
Arch Med Sci. 2021 Feb 10;17(3):579-595
pubmed: 34025827
Front Med (Lausanne). 2020 Nov 17;7:584870
pubmed: 33330541
Tohoku J Exp Med. 2020;252(1):73-84
pubmed: 32908083
J Am Heart Assoc. 2020 Dec 15;9(24):e018475
pubmed: 33092446
Front Med (Lausanne). 2021 Feb 03;8:639804
pubmed: 33614688
Heart Fail Rev. 2021 Sep;26(5):1259-1272
pubmed: 32008148
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Acta Anaesthesiol Scand. 2021 Jan 12;:
pubmed: 33438198
Eur J Gastroenterol Hepatol. 2022 Feb 1;34(2):137-141
pubmed: 33252418
Sci Rep. 2015 May 13;5:9902
pubmed: 25970700
PLoS One. 2020 Dec 15;15(12):e0243600
pubmed: 33320875
J Clin Med. 2020 Jun 18;9(6):
pubmed: 32570882
Thromb Haemost. 2016 Mar;115(3):520-32
pubmed: 26632869
J Cachexia Sarcopenia Muscle. 2021 Apr;12(2):237-251
pubmed: 33511728
Diabetes Metab. 2021 Mar;47(2):101202
pubmed: 33091555
Adv Exp Med Biol. 2021;1327:205-214
pubmed: 34279841
J Clin Anesth. 2020 Dec;67:110005
pubmed: 32707517
EClinicalMedicine. 2020 Sep;26:100504
pubmed: 32838244
Sci Rep. 2020 Oct 15;10(1):17458
pubmed: 33060704
Am J Hypertens. 2020 Dec 31;33(12):1102-1111
pubmed: 32920644
Intervirology. 2020 Dec 9;:1-12
pubmed: 33296901
BMJ. 2020 May 29;369:m1996
pubmed: 32471884
Endocrine. 2021 Feb;71(2):270-272
pubmed: 33219496
Lancet Diabetes Endocrinol. 2020 Oct;8(10):823-833
pubmed: 32798471
Ageing Res Rev. 2020 Mar;58:101024
pubmed: 32006687
Am J Cardiol. 2020 Dec 1;136:149-155
pubmed: 32946859
Semin Cancer Biol. 2021 Aug;73:116-133
pubmed: 32814114
Nat Commun. 2021 Feb 26;12(1):1325
pubmed: 33637713