Direct and Indirect Interactions Promote Complexes of the Lipoprotein LbcA, the CtpA Protease and Its Substrates, and Other Cell Wall Proteins in Pseudomonas aeruginosa.

Bacterial Proteins / genetics Cell Wall / chemistry Endopeptidases / metabolism Lipoproteins / chemistry Mutation N-Acetylmuramoyl-L-alanine Amidase / metabolism Peptide Hydrolases / genetics Peptidoglycan Pseudomonas aeruginosa / genetics Substrate Specificity Type III Secretion Systems / metabolism
Pseudomonas aeruginosa cell envelope proteases

Journal

Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R

Informations de publication

Date de publication:
19 11 2021
Historique:
pubmed: 28 9 2021
medline: 21 12 2021
entrez: 27 9 2021
Statut: ppublish

Résumé

The Pseudomonas aeruginosa lipoprotein LbcA was discovered because it copurified with and promoted the activity of CtpA, a carboxyl-terminal processing protease (CTP) required for type III secretion system function and virulence in a mouse model of acute pneumonia. In this study, we explored the role of LbcA by determining its effect on the proteome and its participation in protein complexes.

Identifiants

DOI: 10.1128/JB.00393-21 PMID: 34570626 PMC: PMC8604077
pubmed: 34570626
doi: 10.1128/JB.00393-21
pmc: PMC8604077
doi:

Substances chimiques

Bacterial Proteins 0
Lipoproteins 0
Peptidoglycan 0
Type III Secretion Systems 0
Endopeptidases EC 3.4.-
Peptide Hydrolases EC 3.4.-
N-Acetylmuramoyl-L-alanine Amidase EC 3.5.1.28

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0039321

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI136901
Pays : United States
Organisme : NIAID NIH HHS
ID : R01AI136901
Pays : United States

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Auteurs

Dolonchapa Chakraborty (D)

Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA.

Andrew J Darwin (AJ)

Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA.
ORCID: 0000-0002-7751-1293

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Cellules › Structures cellulaires › Paroi cellulaire › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › N-acetylmuramoyl-l-alanine amidase › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes bactériens › Polyosides bactériens › Peptidoglycane › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Direct and Indirect Interactions Promote...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Systèmes de translocation des protéines › Systèmes bactériens de sécrétion › Systèmes de sécrétion de type III › Direct and Indirect Interactions Promote...