Hydroxy-Porphyrin as an Effective, Endogenous Molecular Clamp during Early Stages of Amyloid Fibrillization.
Amyloid fibril formation
Hydrogen Bonding
Insulin
Lysozyme
Porphyrin
Journal
Chemistry, an Asian journal
ISSN: 1861-471X
Titre abrégé: Chem Asian J
Pays: Germany
ID NLM: 101294643
Informations de publication
Date de publication:
01 Dec 2021
01 Dec 2021
Historique:
received:
16
08
2021
pubmed:
28
9
2021
medline:
16
12
2021
entrez:
27
9
2021
Statut:
ppublish
Résumé
Amyloid fibril formation of proteins is of great concern in neurodegenerative disease and can be detrimental to the storage and stability of biologics. Recent evidence suggests that insulin fibril formation reduces the efficacy of type II diabetes management and may lead to several complications. To develop anti-amyloidogenic compounds of endogenous origin, we have utilized the hydrogen bond anchoring, π stacking ability of porphyrin, and investigated its role on the inhibition of insulin amyloid formation. We report that hydroxylation and metal removal from the heme moiety yields an excellent inhibitor of insulin fibril formation. Thioflavin T, tyrosine fluorescence, Circular Dichorism (CD) spectroscopy, Field emission scanning electron microscopy (FESEM) and molecular dynamics (MD) simulation studies suggest that hematoporphyrin (HP) having hydrogen bonding ability on both sides is a superior inhibitor compared to hemin and protoporphyrin (PP). Experiments with hen egg white lysozyme (HEWL) amyloid fibril formation also validated the efficacy of endogenous porphyrin based small molecules. Our results will help to decipher a general therapeutic strategy to counter amyloidogenesis.
Identifiants
pubmed: 34570963
doi: 10.1002/asia.202100965
doi:
Substances chimiques
Amyloid
0
Hypoglycemic Agents
0
Porphyrins
0
Protein Aggregates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3931-3936Subventions
Organisme : DST-Inspire
ID : IFA13-CH-120, 2014
Organisme : Science and Engineering Research Board (SERB)
ID : ECR/2016/001935
Organisme : DST-Inspire
Organisme : CSIR
Organisme : SERB
ID : CRG/2020/005610
Organisme : SERB
ID : MTR/2019/00786
Organisme : Novo Nordisk Foundation
ID : NNFSA170028392
Informations de copyright
© 2021 Wiley-VCH GmbH.
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