Hypoblast Formation in Bovine Embryos Does Not Depend on NANOG.
Animals
Apoptosis
/ drug effects
Blastocyst
/ cytology
CRISPR-Cas Systems
Cattle
Cell Differentiation
Cell Lineage
Embryo, Mammalian
/ cytology
Gene Editing
Germ Layers
/ cytology
Mice
Mice, Knockout
Mitogen-Activated Protein Kinase Kinases
/ antagonists & inhibitors
Nanog Homeobox Protein
/ deficiency
Protein Kinase Inhibitors
/ pharmacology
SOXF Transcription Factors
/ metabolism
Signal Transduction
MEK
NANOG
SOX17
bovine preimplantation development
second lineage differentiation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 08 2021
28 08 2021
Historique:
received:
15
07
2021
revised:
24
08
2021
accepted:
25
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
18
11
2021
Statut:
epublish
Résumé
The role of the pluripotency factor NANOG during the second embryonic lineage differentiation has been studied extensively in mouse, although species-specific differences exist. To elucidate the role of NANOG in an alternative model organism, we knocked out
Identifiants
pubmed: 34571882
pii: cells10092232
doi: 10.3390/cells10092232
pmc: PMC8466907
pii:
doi:
Substances chimiques
Nanog Homeobox Protein
0
Protein Kinase Inhibitors
0
SOXF Transcription Factors
0
Mitogen-Activated Protein Kinase Kinases
EC 2.7.12.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 405453332
Organisme : German Center for Diabetes Research
ID : 82DZD00802.
Organisme : Bayerische Forschungsstiftung
ID : AZ-1300-17
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