Endothelial Heterogeneity in Development and Wound Healing.
Animals
Cell Differentiation
/ physiology
Cell Movement
/ physiology
Endothelial Cells
/ pathology
Endothelium
/ immunology
Epithelial-Mesenchymal Transition
Fibrosis
Humans
Neovascularization, Physiologic
/ physiology
Platelet Endothelial Cell Adhesion Molecule-1
Signal Transduction
/ physiology
Transforming Growth Factor beta
Vascular System Injuries
/ physiopathology
Wound Healing
/ genetics
EndMT
angiogenesis
endothelium
heterogeneity
neovascularisation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 09 2021
07 09 2021
Historique:
received:
20
07
2021
revised:
30
08
2021
accepted:
06
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
18
11
2021
Statut:
epublish
Résumé
The vasculature is comprised of endothelial cells that are heterogeneous in nature. From tissue resident progenitors to mature differentiated endothelial cells, the diversity of these populations allows for the formation, maintenance, and regeneration of the vascular system in development and disease, particularly during situations of wound healing. Additionally, the de-differentiation and plasticity of different endothelial cells, especially their capacity to undergo endothelial to mesenchymal transition, has also garnered significant interest due to its implication in disease progression, with emphasis on scarring and fibrosis. In this review, we will pinpoint the seminal discoveries defining the phenotype and mechanisms of endothelial heterogeneity in development and disease, with a specific focus only on wound healing.
Identifiants
pubmed: 34571987
pii: cells10092338
doi: 10.3390/cells10092338
pmc: PMC8469713
pii:
doi:
Substances chimiques
Platelet Endothelial Cell Adhesion Molecule-1
0
Transforming Growth Factor beta
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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