p53 mRNA Metabolism Links with the DNA Damage Response.
ATM kinase
DNA damage response
MDM2
RNA metabolism
RNA-binding proteins
mRNA translation
p53
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
20 09 2021
20 09 2021
Historique:
received:
26
08
2021
revised:
10
09
2021
accepted:
13
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
16
2
2022
Statut:
epublish
Résumé
Human cells are subjected to continuous challenges by different genotoxic stress attacks. DNA damage leads to erroneous mutations, which can alter the function of oncogenes or tumor suppressors, resulting in cancer development. To circumvent this, cells activate the DNA damage response (DDR), which mainly involves cell cycle regulation and DNA repair processes. The tumor suppressor p53 plays a pivotal role in the DDR by halting the cell cycle and facilitating the DNA repair processes. Various pathways and factors participating in the detection and repair of DNA have been described, including scores of RNA-binding proteins (RBPs) and RNAs. It has become increasingly clear that p53's role is multitasking, and p53 mRNA regulation plays a prominent part in the DDR. This review is aimed at covering the p53 RNA metabolism linked to the DDR and highlights the recent findings.
Identifiants
pubmed: 34573428
pii: genes12091446
doi: 10.3390/genes12091446
pmc: PMC8465283
pii:
doi:
Substances chimiques
RNA, Messenger
0
RNA-Binding Proteins
0
Tumor Suppressor Protein p53
0
Untranslated Regions
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Mol Biol. 2017 Oct 27;429(21):3139-3145
pubmed: 27693651
Science. 1990 Nov 30;250(4985):1233-8
pubmed: 1978757
Oncogene. 2014 Jan 30;33(5):611-8
pubmed: 23318444
DNA Repair (Amst). 2007 Jun 1;6(6):830-40
pubmed: 17387044
Oncogene. 2010 Sep 16;29(37):5113-9
pubmed: 20622898
Oncogene. 2006 Nov 2;25(52):6936-47
pubmed: 16983332
Mol Cell Biol. 2005 Jun;25(11):4752-66
pubmed: 15899876
Genes Dev. 2009 Mar 15;23(6):719-28
pubmed: 19261748
Science. 2007 May 25;316(5828):1194-8
pubmed: 17525340
Mol Cell Biol. 2016 Jul 29;36(16):2195-205
pubmed: 27215386
Mol Cell Biol. 2015 Dec;35(23):4006-17
pubmed: 26391949
Klin Onkol. 2018 Winter;31(Suppl 2):63-70
pubmed: 31023026
Nat Rev Cancer. 2009 Dec;9(12):862-73
pubmed: 19935675
Br J Cancer. 2020 Mar;122(5):613-623
pubmed: 31894141
DNA Repair (Amst). 2021 Jul;103:103115
pubmed: 33915415
Nucleic Acids Res. 2017 Sep 29;45(17):10206-10217
pubmed: 28973454
Int J Mol Sci. 2016 Feb 27;17(3):310
pubmed: 26927092
Translation (Austin). 2016 Oct 4;4(2):e1244031
pubmed: 28090421
Nat Rev Mol Cell Biol. 2020 Dec;21(12):765-781
pubmed: 33077885
Cell. 1979 May;17(1):43-52
pubmed: 222475
EMBO J. 1997 Jul 1;16(13):4117-25
pubmed: 9233820
Cell Cycle. 2009 Jan 1;8(1):31-4
pubmed: 19106616
Cancer Res. 1991 Dec 1;51(23 Pt 1):6304-11
pubmed: 1933891
Oncogene. 2011 Apr 14;30(15):1798-811
pubmed: 21170087
Cell Death Differ. 2017 Oct;24(10):1717-1729
pubmed: 28622297
Mol Cell Biol. 1984 Sep;4(9):1689-94
pubmed: 6092932
Mol Pharmacol. 2008 May;73(5):1558-67
pubmed: 18296503
Biochimie. 2020 Dec;179:205-216
pubmed: 33058958
Nat Struct Mol Biol. 2010 Nov;17(11):1358-66
pubmed: 20972445
Trends Genet. 2012 Mar;28(3):128-36
pubmed: 22265392
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2302-6
pubmed: 9482880
Nature. 1979 Mar 15;278(5701):261-3
pubmed: 218111
J Mol Cell Biol. 2019 Mar 1;11(3):187-199
pubmed: 30252118
Nat Commun. 2017 Sep 13;8(1):530
pubmed: 28904350
BMC Cancer. 2019 Sep 13;19(1):915
pubmed: 31519161
J Genet Genomics. 2021 Apr 20;48(4):333-340
pubmed: 34039517
Nat Rev Mol Cell Biol. 2008 May;9(5):402-12
pubmed: 18431400
J Physiol Biochem. 2004 Dec;60(4):287-307
pubmed: 15957248
Nat Rev Mol Cell Biol. 2017 Aug;18(8):495-506
pubmed: 28512351
Gene. 2007 Jun 15;395(1-2):1-7
pubmed: 17395405
Nature. 1993 Apr 29;362(6423):849-52
pubmed: 8479523
Cancer Sci. 2004 Nov;95(11):866-71
pubmed: 15546503
Oncogene. 2013 Jul 18;32(29):3461-9
pubmed: 22986526
J Nucleic Acids. 2010 Jul 25;2010:
pubmed: 20798862
Nature. 1993 Apr 29;362(6423):847-9
pubmed: 8479522
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3351-6
pubmed: 23401530
Nat Cell Biol. 2008 Sep;10(9):1098-105
pubmed: 19160491
Nucleic Acids Res. 2019 Apr 23;47(7):3257-3271
pubmed: 30828720
Signal Transduct Target Ther. 2020 May 1;5(1):60
pubmed: 32355263
NAR Cancer. 2020 Sep;2(3):zcaa028
pubmed: 33015627
Oncotarget. 2017 Apr 10;8(31):51108-51122
pubmed: 28881634
Nature. 2009 Oct 22;461(7267):1071-8
pubmed: 19847258
Trends Cell Biol. 2012 Feb;22(2):97-106
pubmed: 22154076
Front Biosci (Landmark Ed). 2016 Jan 01;21:514-27
pubmed: 26709791
EMBO Rep. 2006 Apr;7(4):404-10
pubmed: 16440000
Nat Commun. 2017 Dec 13;8(1):2103
pubmed: 29235459
Cell Death Dis. 2018 Feb 2;9(2):145
pubmed: 29396424
FEBS Lett. 2005 Jun 13;579(15):3346-54
pubmed: 15943980
Nature. 1991 Jul 25;352(6333):345-7
pubmed: 1852210
Cancer Cell. 2012 Jan 17;21(1):25-35
pubmed: 22264786
Cell Death Differ. 2012 Oct;19(10):1613-22
pubmed: 22522597
Cell. 2017 Sep 7;170(6):1062-1078
pubmed: 28886379
Nucleic Acids Res. 2011 Jan;39(1):213-24
pubmed: 20817677
Biomed Res Int. 2015;2015:708158
pubmed: 26273641
Arch Toxicol. 2015 Apr;89(4):501-17
pubmed: 25618545
EMBO J. 1995 Sep 15;14(18):4442-9
pubmed: 7556087
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8354-9
pubmed: 12821781
Nature. 2007 Jun 21;447(7147):941-50
pubmed: 17581577
Genes Dev. 2011 Jul 15;25(14):1528-43
pubmed: 21764855
Nature. 1992 Jul 2;358(6381):15-6
pubmed: 1614522
Oncogene. 1993 Feb;8(2):307-18
pubmed: 8426740
Elife. 2021 May 06;10:
pubmed: 33955355
Nat Cell Biol. 2012 Feb 19;14(3):318-28
pubmed: 22344029
PLoS One. 2013;8(4):e60208
pubmed: 23577092
EMBO Rep. 2016 Apr;17(4):508-18
pubmed: 26964895
Nat Struct Mol Biol. 2021 Jan;28(1):13-19
pubmed: 33077952
Cell Death Differ. 2013 Feb;20(2):226-34
pubmed: 22935615
Genes Dev. 2010 Oct 1;24(19):2146-56
pubmed: 20837656
Cell Cycle. 2008 Jul 15;7(14):2189-98
pubmed: 18635961
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5056-61
pubmed: 15788536
Nat Cell Biol. 2002 Jun;4(6):462-7
pubmed: 12032546
Mol Cell. 2014 May 8;54(3):500-11
pubmed: 24813712
J Mol Biol. 2017 Oct 27;429(21):3121-3131
pubmed: 27940037
Front Genet. 2020 Dec 23;11:607428
pubmed: 33424929
RNA Biol. 2016 Nov;13(11):1152-1165
pubmed: 27592685
J Biol Chem. 2012 May 11;287(20):16467-76
pubmed: 22433872
Oncogene. 2013 Apr 25;32(17):2169-78
pubmed: 22710720
Nucleic Acids Res. 2015 Dec 2;43(21):10083-101
pubmed: 26519467
Nature. 1997 May 15;387(6630):299-303
pubmed: 9153396
Trends Biochem Sci. 2014 Mar;39(3):141-9
pubmed: 24534650
Mol Biol Evol. 2016 May;33(5):1280-92
pubmed: 26823446
Genes Dev. 2011 Feb 1;25(3):220-5
pubmed: 21289067
Genome Res. 2016 Mar;26(3):331-41
pubmed: 26701625
Cell. 1997 Oct 31;91(3):325-34
pubmed: 9363941
Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a001008
pubmed: 20182602
Cell. 1993 Nov 19;75(4):817-25
pubmed: 8242752
Mutat Res Rev Mutat Res. 2018 Apr - Jun;776:1-9
pubmed: 29807573
Cancer Sci. 2020 Oct;111(10):3416-3425
pubmed: 33403784
Cancers (Basel). 2021 Jul 01;13(13):
pubmed: 34282755
EMBO J. 2019 Sep 16;38(18):e101801
pubmed: 31393028
Int J Mol Sci. 2019 Oct 29;20(21):
pubmed: 31671760
Int J Biochem Cell Biol. 2005 May;37(5):913-9
pubmed: 15743665
Curr Protoc Cytom. 2004 Nov;Chapter 7:Unit 7.27
pubmed: 18770804
Am J Pathol. 2011 Sep;179(3):1257-64
pubmed: 21741933
Mol Cell. 2010 Oct 22;40(2):179-204
pubmed: 20965415
Crit Rev Biochem Mol Biol. 2020 Feb;55(1):33-53
pubmed: 32164444
Nat Rev Mol Cell Biol. 2006 May;7(5):335-46
pubmed: 16612326
Cold Spring Harb Perspect Biol. 2013 Sep 01;5(9):
pubmed: 24003211
Oncogene. 2006 Aug 3;25(33):4613-9
pubmed: 16607284
Oncogene. 2004 Jan 22;23(3):631-8
pubmed: 14737098
Oncol Rep. 2021 Aug;46(2):
pubmed: 34165168
Cell. 2005 Oct 7;123(1):49-63
pubmed: 16213212
Mol Cell. 2012 Feb 24;45(4):505-16
pubmed: 22365830
Int J Mol Sci. 2018 Nov 27;19(12):
pubmed: 30486342
Nucleic Acids Res. 2014 Sep;42(15):10099-111
pubmed: 25123665
Nat Rev Cancer. 2014 May;14(5):359-70
pubmed: 24739573
DNA Repair (Amst). 2016 Feb;38:94-101
pubmed: 26704428
Cold Spring Harb Perspect Med. 2016 May 02;6(5):
pubmed: 27048304
Cell. 1993 Nov 19;75(4):805-16
pubmed: 8242751
Oncogene. 2017 Feb 2;36(5):723-730
pubmed: 27375027
Nature. 1997 May 15;387(6630):296-9
pubmed: 9153395
Nature. 2000 Nov 16;408(6810):307-10
pubmed: 11099028
J Biol Chem. 2011 Dec 16;286(50):42855-62
pubmed: 22033922
Oncogene. 1999 Nov 11;18(47):6419-24
pubmed: 10597243
Genome Res. 2018 Sep;28(9):1405-1414
pubmed: 30108179
Annu Rev Biochem. 2004;73:39-85
pubmed: 15189136
Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a000950
pubmed: 20457558
Mol Cell Biol. 2000 Aug;20(15):5602-18
pubmed: 10891498
Biochem Biophys Res Commun. 2016 Mar 25;472(1):95-100
pubmed: 26903295
Front Mol Biosci. 2019 Aug 02;6:61
pubmed: 31428617