Liquid Biopsy in Melanoma: Significance in Diagnostics, Prediction and Treatment Monitoring.
Animals
Biomarkers
Biomarkers, Tumor
/ genetics
Cell Line, Tumor
Circulating Tumor DNA
/ blood
Clinical Trials as Topic
Exosomes
/ metabolism
Extracellular Vesicles
/ pathology
Humans
Immunotherapy
Liquid Biopsy
/ methods
Melanoma
/ blood
Mice
Mutation
Neoplastic Cells, Circulating
Precision Medicine
Prognosis
Skin Neoplasms
/ blood
Melanoma, Cutaneous Malignant
circulating melanoma cells (CMCs)
circulating tumor cells (CTCs)
immunotherapy
liquid biopsy
malignant melanoma
metastasis
targeted treatment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Sep 2021
08 Sep 2021
Historique:
received:
28
07
2021
revised:
25
08
2021
accepted:
06
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Liquid biopsy is a common term referring to circulating tumor cells and other biomarkers, such as circulating tumor DNA (ctDNA) or extracellular vesicles. Liquid biopsy presents a range of clinical advantages, such as the low invasiveness of the blood sample collection and continuous control of the tumor progression. In addition, this approach enables the mechanisms of drug resistance to be determined in various methods of cancer treatment, including immunotherapy. However, in the case of melanoma, the application of liquid biopsy in patient stratification and therapy needs further investigation. This review attempts to collect all of the relevant and recent information about circulating melanoma cells (CMCs) related to the context of malignant melanoma and immunotherapy. Furthermore, the biology of liquid biopsy analytes, including CMCs, ctDNA, mRNA and exosomes, as well as techniques for their detection and isolation, are also described. The available data support the notion that thoughtful selection of biomarkers and technologies for their detection can contribute to the development of precision medicine by increasing the efficacy of cancer diagnostics and treatment.
Identifiants
pubmed: 34575876
pii: ijms22189714
doi: 10.3390/ijms22189714
pmc: PMC8468624
pii:
doi:
Substances chimiques
Biomarkers
0
Biomarkers, Tumor
0
Circulating Tumor DNA
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : SIRIC Montpellier Cancer Grant
ID : INCa_Inserm_DGOS_12553
Organisme : European Union Horizon 2020 Research and Innovation program
ID : No 765492
Organisme : Fondation ARC pour la recherche sur le cancer
ID : ERA-NET TRANSCAN 2 JTC 2016 PROLIPSY
Organisme : The National Centre for Research and Development
ID : ERA-NET TRANSCAN/01/2018
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