Potassium Alginate Oligosaccharides Alter Gut Microbiota, and Have Potential to Prevent the Development of Hypertension and Heart Failure in Spontaneously Hypertensive Rats.
blood pressure
gut microbiota
heart failure
potassium alginate oligosaccharides
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Sep 2021
11 Sep 2021
Historique:
received:
22
07
2021
revised:
31
08
2021
accepted:
06
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
25
2
2023
Statut:
epublish
Résumé
Food-derived oligosaccharides show promising therapeutic potential in lowering blood pressure (BP), but the mechanism is poorly understood. Recently, the potential role of gut microbiota (GM) in hypertension has been investigated, but the specific GM signature that may participate in hypertension remains unclear. To test the potassium alginate oligosaccharides (PAO) mechanism in lowering BP and specific microbial signature changes in altering GM, we administered various dosages of PAO in 40 spontaneously hypertensive rats for a duration of six weeks. We analyzed BP, sequenced the 16S ribosomal DNA gene in the cecum content, and gathered RNA-seq data in cardiac tissues. We showed that the oral administration of PAO could significantly decrease systolic BP and mean arterial pressure. Transcriptome analyses demonstrated that the protective effects of developing heart failure were accompanied by down-regulating of the Natriuretic Peptide A gene expression and by decreasing the concentrations of angiotensin II and atrial natriuretic peptide in plasma. In comparison to the Vehicle control, PAO could increase the microbial diversity by altering the composition of GM. PAO could also decrease the ratio of Firmicutes to Bacteroidetes by decreasing the abundance of
Identifiants
pubmed: 34575987
pii: ijms22189823
doi: 10.3390/ijms22189823
pmc: PMC8470992
pii:
doi:
Substances chimiques
Alginates
0
Oligosaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31872893
Organisme : Key Research and Development Project Foundation of Shandong Province
ID : 2017YYSP003
Organisme : Natural Science Foundation of Shandong Province
ID : ZR2017MD006
Références
Lancet. 2013 Jun 8;381(9882):1987-2015
pubmed: 23746901
Hypertension. 2014 Nov;64(5):924-8
pubmed: 25156167
Plant Foods Hum Nutr. 2018 Mar;73(1):1-6
pubmed: 29230708
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W316-22
pubmed: 21715386
Hypertension. 2016 Feb;67(2):469-74
pubmed: 26711739
Nature. 2012 Oct 4;490(7418):55-60
pubmed: 23023125
Circulation. 2019 Mar 12;139(11):1407-1421
pubmed: 30586752
Circulation. 2005 Jan 25;111(3):343-8
pubmed: 15655130
Mol Carcinog. 2016 Dec;55(12):2247-2259
pubmed: 26824226
Nutrients. 2020 Sep 29;12(10):
pubmed: 33003455
Nature. 2014 Sep 4;513(7516):59-64
pubmed: 25079328
Regul Pept. 2001 Apr 20;98(3):105-10
pubmed: 11231039
Physiol Genomics. 2015 Jun;47(6):187-97
pubmed: 25829393
Kidney Int. 2013 Jun;83(6):1118-29
pubmed: 23447063
Hypertension. 2015 Jun;65(6):1331-40
pubmed: 25870193
FASEB J. 1991 Dec;5(15):3037-46
pubmed: 1835945
Circulation. 2016 Jan 26;133(4):e38-360
pubmed: 26673558
Lancet. 2005 Jan 15-21;365(9455):217-23
pubmed: 15652604
Circulation. 2019 Jul 9;140(2):101-102
pubmed: 31283373
J Hum Hypertens. 2019 Sep;33(9):641-647
pubmed: 31341238
Microbiome. 2017 Feb 1;5(1):14
pubmed: 28143587
Microbiome. 2020 Jul 25;8(1):112
pubmed: 32711581
Clin Exp Hypertens. 2013;35(8):607-13
pubmed: 23484864
Elife. 2013 Nov 05;2:e01202
pubmed: 24192039
Physiol Genomics. 2017 Feb 1;49(2):96-104
pubmed: 28011881
J Hypertens. 2000 May;18(5):567-73
pubmed: 10826559
Int J Mol Med. 2019 Aug;44(2):513-522
pubmed: 31173179
Development. 2014 Nov;141(22):4199-205
pubmed: 25371357
Biomed Pharmacother. 2010 Apr;64(4):291-5
pubmed: 19932586
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Bioinformatics. 2009 May 1;25(9):1105-11
pubmed: 19289445
Fitoterapia. 2016 Jul;112:244-53
pubmed: 27343367
Cell Stem Cell. 2018 Sep 6;23(3):382-395.e5
pubmed: 30100166
Nat Commun. 2012;3:1245
pubmed: 23212374
Carbohydr Polym. 2018 Jan 1;179:173-185
pubmed: 29111040
J Am Coll Cardiol. 2019 Mar 19;73(10):1173-1184
pubmed: 30871701
Protein Cell. 2018 May;9(5):416-431
pubmed: 29725935
J Am Heart Assoc. 2019 Feb 19;8(4):e010721
pubmed: 30755073
Mar Drugs. 2019 Mar 18;17(3):
pubmed: 30889794
Mol Med. 2015 Jan 20;20:516-26
pubmed: 25171109
Circ Res. 2017 Jan 20;120(2):312-323
pubmed: 27799253
J Nutr. 2004 Apr;134(4):980S-8S
pubmed: 15051858
Adv Physiol Educ. 2017 Jun 1;41(2):179-185
pubmed: 28377431
Drug Des Devel Ther. 2017 Aug 18;11:2387-2397
pubmed: 28860710
Appl Microbiol Biotechnol. 2020 Apr;104(8):3541-3554
pubmed: 32103315
Circ Res. 2006 Apr 28;98(8):988-9
pubmed: 16645147
Eur Heart J. 2020 Nov 21;41(44):4259-4267
pubmed: 32869053
Biomed Pharmacother. 2019 Aug;116:109040
pubmed: 31170664
Circulation. 2016 Aug 9;134(6):441-50
pubmed: 27502908
Heart Fail Rev. 2014 Mar;19(2):173-85
pubmed: 23124941
Mol Syst Biol. 2014 Nov 28;10:766
pubmed: 25432777
Circulation. 2017 Mar 7;135(10):964-977
pubmed: 27927713
Clin Exp Hypertens. 2012;34(5):305-10
pubmed: 22690942
Int J Biol Sci. 2017 Feb 12;13(3):276-285
pubmed: 28367092
Clin Sci (Lond). 2003 Aug;105(2):141-60
pubmed: 12710884
Circulation. 2014 Aug 5;130(6):496-507
pubmed: 24899690