Impact of DICER1 and DROSHA on the Angiogenic Capacity of Human Endothelial Cells.
DICER1
DROSHA
RNA interference
angiogenesis
endothelial cells
microRNA biogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Sep 2021
12 Sep 2021
Historique:
received:
20
08
2021
revised:
08
09
2021
accepted:
10
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
25
2
2023
Statut:
epublish
Résumé
RNAi-mediated knockdown of DICER1 and DROSHA, enzymes critically involved in miRNA biogenesis, has been postulated to affect the homeostasis and the angiogenic capacity of human endothelial cells. To re-evaluate this issue, we reduced the expression of DICER1 or DROSHA by RNAi-mediated knockdown and subsequently investigated the effect of these interventions on the angiogenic capacity of human umbilical vein endothelial cells (HUVEC)
Identifiants
pubmed: 34576018
pii: ijms22189855
doi: 10.3390/ijms22189855
pmc: PMC8471234
pii:
doi:
Substances chimiques
DICER1 protein, human
EC 3.1.26.3
DROSHA protein, human
EC 3.1.26.3
Ribonuclease III
EC 3.1.26.3
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Regional Development Fund of the European Commission
ID : W21029490
Organisme : Publication Fund of the Martin-Luther-University Halle/Wittenberg
ID : VAT DE 811353703
Références
Cell. 2019 Mar 7;176(6):1248-1264
pubmed: 30849371
Int J Mol Sci. 2021 Apr 14;22(8):
pubmed: 33920030
Cancer Res. 2006 Apr 1;66(7):3649-57
pubmed: 16585190
Microcirculation. 2020 Apr;27(3):e12602
pubmed: 31863494
RNA. 2012 Mar;18(3):472-84
pubmed: 22282338
Circ Res. 2007 Jul 6;101(1):59-68
pubmed: 17540974
Circ Res. 2020 Jul 3;127(2):310-329
pubmed: 32833569
Angiogenesis. 2003;6(4):303-9
pubmed: 15166499
Cell Metab. 2019 Sep 3;30(3):414-433
pubmed: 31484054
Nat Rev Mol Cell Biol. 2019 Jan;20(1):21-37
pubmed: 30108335
Postepy Hig Med Dosw (Online). 2017 May 5;71(0):339-351
pubmed: 28513458
Nat Protoc. 2009;4(4):495-505
pubmed: 19300443
Biochem Biophys Res Commun. 2014 Jan 24;443(4):1211-7
pubmed: 24388985
Pharmacology. 2009;84(5):264-70
pubmed: 19776663
J Cell Biol. 1998 Nov 30;143(5):1341-52
pubmed: 9832561
Genes Dev. 2014 May 15;28(10):1054-67
pubmed: 24788094
Sci Rep. 2015 Aug 21;5:13316
pubmed: 26294080
Nat Rev Mol Cell Biol. 2016 Oct;17(10):611-25
pubmed: 27461391
Biochem Pharmacol. 2016 Mar 15;104:139-47
pubmed: 26903388
Circ Res. 2008 Oct 24;103(9):1037-46
pubmed: 18802021
Nat Protoc. 2007;2(2):329-33
pubmed: 17406593
Oncotarget. 2016 Dec 20;7(51):84299-84313
pubmed: 27732931
J Biol Chem. 2012 Aug 17;287(34):29003-20
pubmed: 22745131
J Biol Chem. 2005 Mar 11;280(10):9330-5
pubmed: 15613470
Hypertension. 2009 Sep;54(3):652-8
pubmed: 19652084
Circ Res. 2007 Apr 27;100(8):1164-73
pubmed: 17379831
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Nat Protoc. 2009;4(8):1202-15
pubmed: 19644460
World J Gastroenterol. 2010 Jan 14;16(2):217-24
pubmed: 20066741
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14082-7
pubmed: 18779589
J Cell Sci. 2016 Mar 15;129(6):1234-49
pubmed: 26857814
Front Oncol. 2020 Nov 27;10:581007
pubmed: 33330058
Oncogene. 2002 Apr 11;21(16):2504-12
pubmed: 11971185
Cell. 2007 Aug 24;130(4):691-703
pubmed: 17719546