Therapeutic Effects of an Anti-sialyl Lewis X Antibody in a Murine Model of Allergic Asthma.
Animals
Antibodies, Monoclonal
/ administration & dosage
Asthma
/ complications
Bone Marrow
/ pathology
Cell Differentiation
Disease Models, Animal
Eosinophils
/ immunology
Female
Hypersensitivity
/ complications
Immunity
Lung
/ immunology
Mice, Inbred C57BL
Models, Biological
P-Selectin
/ metabolism
Protein Binding
Sialyl Lewis X Antigen
/ immunology
antibody
asthma
druggable targets
leukocyte infiltration
sialyl Lewis X
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Sep 2021
15 Sep 2021
Historique:
received:
11
08
2021
revised:
02
09
2021
accepted:
13
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Asthma is an allergic disease that causes severe infiltration of leukocytes into the lungs. Leukocyte infiltration is mediated by the binding of sialyl Lewis X (sLe
Identifiants
pubmed: 34576124
pii: ijms22189961
doi: 10.3390/ijms22189961
pmc: PMC8471066
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
P-Selectin
0
Sialyl Lewis X Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Agency for Medical Research and Development
ID : 20ae0101034h0005
Organisme : Japan Society for the Promotion of Science
ID : 20H03379
Organisme : Japan Society for the Promotion of Science
ID : 15K18869
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