Sequential Injection Analysis for Automation and Evaluation of Drug Liberation Profiles: Clotrimazole Liberation Monitoring.
Franz cell
clotrimazole
kinetic profile
liberation study
sequential injection analysis
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 Sep 2021
12 Sep 2021
Historique:
received:
23
08
2021
revised:
06
09
2021
accepted:
09
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
1
12
2021
Statut:
epublish
Résumé
A fully automated sequential injection system was tested in terms of its application in liberation testing, and capabilities and limitations were discussed for clotrimazole liberation from three semisolid formulations. An evaluation based on kinetic profiles obtained in short and longer sampling intervals and steady-state flux values were applied as traditional methods. The obtained clotrimazole liberation profile was faster in the case of Delcore and slower for Clotrimazol AL and Canesten cream commercial formulations. The steady-state flux values for the tested formulations were 52 µg cm
Identifiants
pubmed: 34577009
pii: molecules26185538
doi: 10.3390/molecules26185538
pmc: PMC8467677
pii:
doi:
Substances chimiques
Antifungal Agents
0
Clotrimazole
G07GZ97H65
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : CZ.02.1.01/0.0/0.0/15_003/0000465
Organisme : Univerzita Karlova v Praze
ID : SVV 260 548
Organisme : International Visegrad Fund
ID : 21930006
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