Effects of Supplementation with Folic Acid and Its Combinations with Other Nutrients on Cognitive Impairment and Alzheimer's Disease: A Narrative Review.
Alzheimer’s disease
cognitive function
folic acid
mild cognitive impairment
vascular dementia
vitamin supplementation
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
26 Aug 2021
26 Aug 2021
Historique:
received:
16
07
2021
revised:
04
08
2021
accepted:
20
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
23
11
2021
Statut:
epublish
Résumé
Cognitive impairment and Alzheimer's Disease, among other cognitive dysfunctions, has been recognized as a major public health problem. Folic acid is a well-known essential nutrient whose deficiency has been linked to neurocognitive dysfunctions, owing to hyperhomocysteinemia, an independent risk factor for cardio- and cerebrovascular diseases, including cognitive impairment, Alzheimer's Disease, and vascular dementia. However, to date, there is certain controversy about the efficacy of vitamin supplementation in patients with these pathologies. Therefore, we have reviewed the available dietary intervention studies based on folic acid, either alone or in combination with different vitamins or nutrients into the progression of Alzheimer's Disease and Cognitive impairment, highlighting the cognition and biochemical markers employed for the evaluation of the disease progression. Undeniably, the compiled information supports the potential benefits of vitamin supplementation in these pathologies, especially relevant to the aging process and quality of life, although more research is urgently needed to confirm these positive findings.
Identifiants
pubmed: 34578844
pii: nu13092966
doi: 10.3390/nu13092966
pmc: PMC8470370
pii:
doi:
Substances chimiques
Vitamin B Complex
12001-76-2
Folic Acid
935E97BOY8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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