Human Milk Oligosaccharide 3'-GL Improves Influenza-Specific Vaccination Responsiveness and Immunity after Deoxynivalenol Exposure in Preclinical Models.
Adaptive Immunity
/ drug effects
Animals
Caco-2 Cells
Cecum
/ drug effects
Diet
Fatty Acids, Volatile
/ metabolism
Female
Food Contamination
Humans
Influenza, Human
/ immunology
Intestines
/ drug effects
Mice, Inbred C57BL
Milk, Human
/ chemistry
Mycotoxins
/ immunology
Oligosaccharides
/ pharmacology
Spleen
/ drug effects
Th1 Cells
/ metabolism
Trichothecenes
/ immunology
Trisaccharides
/ pharmacology
Vaccination
Vaccines
/ immunology
delayed-type hypersensitivity
deoxynivalenol
human milk oligosaccharides
immune response
mycotoxin
vaccination
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 Sep 2021
14 Sep 2021
Historique:
received:
16
08
2021
revised:
03
09
2021
accepted:
10
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
12
11
2021
Statut:
epublish
Résumé
Deoxynivalenol (DON), a highly prevalent mycotoxin food contaminant, is known to have immunotoxic effects. In the current study, the potential of dietary interventions with specific mixtures of trans-galactosyl-oligosaccharides (TOS) to alleviate these effects were assessed in a murine influenza vaccination model. Vaccine-specific immune responses were measured in C57Bl/6JOlaHsd mice fed diets containing DON, TOS or a combination, starting 2 weeks before the first vaccination. The direct effects of TOS and its main oligosaccharide, 3'-galactosyl-lactose (3'-GL), on DON-induced damage were studied in Caco-2 cells, as an in vitro model of the intestinal epithelial barrier. Exposure to DON significantly reduced vaccine-specific immune responses and the percentages of Tbet
Identifiants
pubmed: 34579070
pii: nu13093190
doi: 10.3390/nu13093190
pmc: PMC8466816
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Mycotoxins
0
Oligosaccharides
0
Trichothecenes
0
Trisaccharides
0
Vaccines
0
3'-galactosyllactose
32694-82-9
deoxynivalenol
JT37HYP23V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Br J Nutr. 2017 Jan;117(2):237-247
pubmed: 28179042
Nat Immunol. 2011 Jan;12(1):5-9
pubmed: 21169997
J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S80-3
pubmed: 15220665
Front Pediatr. 2018 Jul 02;6:190
pubmed: 30013961
Allergy. 2015 Sep;70(9):1091-102
pubmed: 25966668
Interdiscip Toxicol. 2010 Sep;3(3):94-9
pubmed: 21217881
J Pediatr Gastroenterol Nutr. 2017 May;64(5):789-798
pubmed: 27602704
Brain Behav Immun. 2014 Mar;37:197-206
pubmed: 24333160
J Dairy Sci. 1993 Mar;76(3):892-7
pubmed: 8463496
Toxicol Lett. 2004 Oct 10;153(1):61-73
pubmed: 15342082
J Pediatr Gastroenterol Nutr. 2005 Aug;41(2):186-90
pubmed: 16056097
Int Immunopharmacol. 2007 Dec 5;7(12):1582-7
pubmed: 17920536
Carbohydr Res. 1988 Jul 15;178:79-91
pubmed: 3274083
Immunobiology. 2007;212(8):655-66
pubmed: 17869643
Cancer Res. 2011 Mar 1;71(5):1989-98
pubmed: 21363926
Blood. 2013 Jun 13;121(24):4930-7
pubmed: 23645836
Toxicology. 1988 Feb;48(2):155-66
pubmed: 3257592
Int Immunopharmacol. 2006 Aug;6(8):1277-86
pubmed: 16782540
Toxicol Lett. 2013 Aug 14;221(2):152-63
pubmed: 23791694
Benef Microbes. 2019 Apr 19;10(3):279-291
pubmed: 30773928
Front Immunol. 2020 May 07;11:801
pubmed: 32457747
Nutrients. 2014 Sep 25;6(9):3942-67
pubmed: 25255831
FASEB J. 2014 Jun;28(6):2414-29
pubmed: 24568843
Toxins (Basel). 2013 Apr 23;5(4):784-820
pubmed: 23612752
Microbiology (Reading). 2017 Oct;163(10):1420-1428
pubmed: 28920844
Acta Paediatr Suppl. 2003 Sep;91(441):64-7
pubmed: 14599044
Toxins (Basel). 2019 Nov 14;11(11):
pubmed: 31739567
J Agric Food Chem. 2015 Dec 23;63(50):10862-72
pubmed: 26621571
Immunol Today. 2000 May;21(5):204-6
pubmed: 10782048
CSH Protoc. 2008 May 01;2008:pdb.prot4986
pubmed: 21356829
J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):296-301
pubmed: 28114245
PLoS One. 2013 Sep 20;8(9):e75148
pubmed: 24073243
Toxicol Sci. 2005 Sep;87(1):134-45
pubmed: 15958657
J Dev Orig Health Dis. 2011 Apr;2(2):112-23
pubmed: 25140925
Vaccine. 2010 Aug 9;28(35):5711-7
pubmed: 20600499
BMC Biol. 2013 May 21;11:61
pubmed: 23692866
J Nutr. 2019 May 1;149(5):856-869
pubmed: 31050747
Br J Nutr. 2005 Sep;94(3):452-81
pubmed: 16176618
Environ Health Perspect. 2001 Aug;109(8):757-64
pubmed: 11564609
PLoS One. 2015 Sep 24;10(9):e0138975
pubmed: 26402906
J Nutr. 2016 Feb;146(2):358-67
pubmed: 26701795
Front Pediatr. 2018 Sep 10;6:239
pubmed: 30250836
Toxins (Basel). 2015 Jun 09;7(6):2071-95
pubmed: 26067367
Physiol Rev. 2007 Apr;87(2):545-64
pubmed: 17429041
Toxicon. 2010 Jan;55(1):73-80
pubmed: 19635492
Front Immunol. 2018 Mar 09;9:452
pubmed: 29593719
J Nutr. 2015 Jul;145(7):1604-13
pubmed: 26019243
Mol Nutr Food Res. 2014 Feb;58(2):384-93
pubmed: 24039030
Acta Paediatr Suppl. 2005 Oct;94(449):18-21
pubmed: 16214760
J Leukoc Biol. 2010 Mar;87(3):501-8
pubmed: 20007247
Curr Drug Metab. 2008 Nov;9(9):893-900
pubmed: 18991586
Nutrients. 2020 Jun 30;12(7):
pubmed: 32629970
Immunology. 2018 Jun;154(2):220-229
pubmed: 29569377
Mucosal Immunol. 2016 Nov;9(6):1477-1486
pubmed: 26883726
Nat Commun. 2018 Nov 27;9(1):5010
pubmed: 30479342
Crit Rev Immunol. 2007;27(2):97-140
pubmed: 17725499
Int Immunopharmacol. 2010 May;10(5):619-25
pubmed: 20206301
Int J Biol Macromol. 2018 May;111:667-679
pubmed: 29339290
Toxicol Sci. 2007 Feb;95(2):412-26
pubmed: 17090620
Front Immunol. 2019 Jul 31;10:1773
pubmed: 31417553
Carbohydr Res. 2000 Apr 20;325(3):202-10
pubmed: 10795811
Neurogastroenterol Motil. 2012 Jun;24(6):503-12
pubmed: 22583600
Front Nutr. 2017 Apr 10;4:11
pubmed: 28443284