The expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma.
CDH3
immunohistochemistry
lymph node metastasis
survival
tongue squamous cell carcinoma
Journal
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
ISSN: 1600-0463
Titre abrégé: APMIS
Pays: Denmark
ID NLM: 8803400
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
26
02
2021
accepted:
19
08
2021
pubmed:
29
9
2021
medline:
24
11
2021
entrez:
28
9
2021
Statut:
ppublish
Résumé
P-cadherin (CDH3) is a cell-to-cell adhesion molecule that regulates several cellular homeostatic processes in normal tissues. Lack of CDH3 expression is associated with aggressive behavior in oral squamous cell carcinoma (OSCC). Previous studies have shown that CDH3 is downregulated in high-grade OSCC and its reduced expression is predictive for poorer survival. The aim of this study was to evaluate the expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma (TSCC). A retrospective series of 211 TSCC and 50 lymph node samples were stained immunohistochemically with polyclonal antibody (anti-CDH3). CDH3 expression was assessed semi-quantitatively with light microscopy. Fisher's exact test was used to compare patient and tumor characteristics, and the correlations were tested by Spearman correlation. Survival curves were drawn by the Kaplan-Meier method and analyzed by the log-rank test. Univariate and multivariate Cox regression was used to estimate the association between CDH3 expression and survival. CDH3 expression did not affect TSCC patient's disease-specific survival or overall survival. Strong CDH3 expression in the primary tumor predicted poor disease-specific and overall survival in patients with recurrent disease. CDH3 expression in lymph nodes without metastasis was negative in all cases. CDH3 expression was positive in all lymph node metastases with extranodal extension. In contrast to previous report about the prognostic value of CDH3 in OSCC, we were not able to validate the result in TSCC.
Substances chimiques
CDH3 protein, human
0
Cadherins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
717-728Subventions
Organisme : Competitive Research Funding of Tampere Medical Research Fund & Tampere University Hospital
Organisme : Finnish Medical Foundation
Organisme : Finnish Association of Otorhinolaryngology and Head & Neck Surgery
Organisme : Minerva Foundation
Organisme : Emil Aaltonen Foundation
Organisme : Väinö and Laina Kivi Foundation
Organisme : Paulo Foundation
Organisme : Jane & Aatos Erkko Foundation
Organisme : The Foundation of Finnish Female Dentist
Organisme : The Finnish-Norwegian foundation of Medicine
Informations de copyright
© 2021 Scandinavian Societies for Medical Microbiology and Pathology.
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