Design of Lipid-Based Nanocarriers via Cation Modulation of Ethanol-Interdigitated Lipid Membranes.

1,2-Dipalmitoylphosphatidylcholine Cations Ethanol Phosphatidylcholines Scattering, Small Angle

Journal

Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
Titre abrégé: Langmuir
Pays: United States
ID NLM: 9882736

Informations de publication

Date de publication:
12 10 2021
Historique:
pubmed: 29 9 2021
medline: 25 2 2023
entrez: 28 9 2021
Statut: ppublish

Résumé

Short-chain alcohols (i.e., ethanol) can induce membrane interdigitation in saturated-chain phosphatidylcholines (PCs). In this process, alcohol molecules intercalate between phosphate heads, increasing lateral separation and favoring hydrophobic interactions between opposing acyl chains, which interpenetrate forming an interdigitated phase. Unraveling mechanisms underlying the interactions between ethanol and model lipid membranes has implications for cell biology, biochemistry, and for the formulation of lipid-based nanocarriers. However, investigations of ethanol-lipid membrane systems have been carried out in deionized water, which limits their applicability. Here, using a combination of small- and wide-angle X-ray scattering, small-angle neutron scattering, and all-atom molecular dynamics simulations, we analyzed the effect of varying CaCl

Identifiants

DOI: 10.1021/acs.langmuir.1c02076 PMID: 34581180
pubmed: 34581180
doi: 10.1021/acs.langmuir.1c02076
doi:

Substances chimiques

Cations 0
Phosphatidylcholines 0
1,2-Dipalmitoylphosphatidylcholine 2644-64-6
Ethanol 3K9958V90M

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11909-11921

Auteurs

Valeria Nele (V)

Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
ORCID: 0000-0002-7263-7209

Margaret N Holme (MN)

Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
ORCID: 0000-0002-7314-9493

M Harunur Rashid (MH)

School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.
Department of Mathematics and Physics, North South University, Bashundhara, Dhaka 1229, Bangladesh.
ORCID: 0000-0001-5044-2315

Hanna M G Barriga (HMG)

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

Tu C Le (TC)

School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.
ORCID: 0000-0003-3552-8211

Michael R Thomas (MR)

Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
London Centre for Nanotechnology and Department of Biochemical Engineering, University College London, 17-19 Gordon Street, London WC1H 0AH, U.K.

James J Doutch (JJ)

ISIS Neutron and Muon Source, STFC, Rutherford Appleton Laboratory, Didcot OX11 ODE, U.K.
ORCID: 0000-0003-0747-8368

Irene Yarovsky (I)

School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.
ORCID: 0000-0002-4033-5150

Molly M Stevens (MM)

Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
ORCID: 0000-0002-7335-266X

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Classifications MeSH

questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidylcholines › 1,2-Dipalmitoylphosphatidylcholine › Design of Lipid-Based Nanocarriers via Cation...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Design of Lipid-Based Nanocarriers via Cation...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Design of Lipid-Based Nanocarriers via Cation...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidylcholines › Design of Lipid-Based Nanocarriers via Cation...
questionsmedicales.fr › Phénomènes physiques › Diffusion de rayonnements › Diffusion aux petits angles › Design of Lipid-Based Nanocarriers via Cation...