Aquaporins in pancreatic ductal adenocarcinoma.
Aquaporin
PDAC
cancer
exocrine pancreas
pancreatic ductal adenocarcinoma
Journal
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
ISSN: 1600-0463
Titre abrégé: APMIS
Pays: Denmark
ID NLM: 8803400
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
01
07
2021
accepted:
24
08
2021
pubmed:
29
9
2021
medline:
24
11
2021
entrez:
28
9
2021
Statut:
ppublish
Résumé
Aquaporins are water channel proteins facilitating passive transport of water across cellular membranes. Aquaporins are over- or ectopically expressed in a multitude of cancers, including pancreatic ductal adenocarcinoma, which is a highly aggressive cancer with low survival rate. Evidence suggests that aquaporins can affect multiple cellular processes involved in cancer development and progression including epithelial-mesenchymal transition, cellular migration, cell proliferation, invasion, and cellular adhesions. In pancreatic ductal adenocarcinoma, aquaporin-1, aquaporin-3, and aquaporin-5 are overexpressed and have been associated with metastatic processes and poor survival. Thus, aquaporin expression has been suggested as diagnostic markers and therapeutic targets in pancreatic ductal adenocarcinoma.
Substances chimiques
Aquaporins
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
700-705Informations de copyright
© 2021 Scandinavian Societies for Medical Microbiology and Pathology.
Références
Denker BM, Smith BL, Kuhajda FP, Agre P. Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. J Biol Chem. 1988;263(30):15634-42.
Matsuzaki T, Suzuki T, Koyama H, Tanaka S, Takata K. Water channel protein AQP3 is present in epithelia exposed to the environment of possible water loss. J Histochem Cytochem. 1999;47(10):1275-86.
Burghardt B, Elkaer ML, Kwon TH, Racz GZ, Varga G, Steward MC, et al. Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut. 2003;52(7):1008-16.
Deen P, Verdijk M, Knoers N, Wieringa B, Monnens L, van Os C, et al. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science. 1994;264(5155):92-5.
Xu DL, Martin PY, Ohara M, St John J, Pattison T, Meng X, et al. Upregulation of aquaporin-2 water channel expression in chronic heart failure rat. J Clin Invest. 1997;99(7):1500-5.
Marlar S, Jensen HH, Login FH, Nejsum LN. Aquaporin-3 in cancer. Int J Mol Sci. 2017;18(10):2106.
Jensen HH, Login FH, Koffman JS, Kwon TH, Nejsum LN. The role of aquaporin-5 in cancer cell migration: a potential active participant. Int J Biochem Cell Biol. 2016;79:271-6.
Tomita Y, Dorward H, Yool A, Smith E, Townsend A, Price T, et al. Role of aquaporin 1 signalling in cancer development and progression. Int J Mol Sci. 2017;18(2):299.
Verkman AS, Mitra AK. Structure and function of aquaporin water channels. Am J Physiol Renal Physiol. 2000;278(1):F13-28.
Hurley PT, Ferguson CJ, Kwon T-H, Andersen M-L, Norman AG, Steward MC, et al. Expression and immunolocalization of aquaporin water channels in rat exocrine pancreas. Am J Physiol Gastrointest Liver Physiol. 2001;280(4):G701-G9.
Cho S-J, Sattar AKMA, Jeong E-H, Satchi M, Cho JA, Dash S, et al. Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles. Proc Natl Acad Sci USA. 2002;99(7):4720-4.
Direito I, Paulino J, Vigia E, Brito MA, Soveral G. Differential expression of aquaporin-3 and aquaporin-5 in pancreatic ductal adenocarcinoma. J Surg Oncol. 2017;115(8):980-96.
Ko SBH, Naruse S, Kitagawa M, Ishiguro H, Furuya S, Mizuno N, et al. Aquaporins in rat pancreatic interlobular ducts. Am J Physiol Gastrointest Liver Physiol. 2002;282(2):G324-31.
Venglovecz V, Pallagi P, Kemény LV, Balázs A, Balla Z, Becskeházi E, et al. The importance of aquaporin 1 in pancreatitis and its relation to the CFTR Cl(-) channel. Front Physiol. 2018;9:854.
Ma T, Jayaraman S, Wang KS, Song Y, Yang B, Li J, et al. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol. 2001;280(1):C126-34.
Yang B, Song Y, Zhao D, Verkman AS. Phenotype analysis of aquaporin-8 null mice. Am J Physiol Cell Physiol. 2005;288(5):C1161-C70.
Itoh T, Rai T, Kuwahara M, Ko SBH, Uchida S, Sasaki S, et al. Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Biochem Biophys Res Comm. 2005;330(3):832-8.
Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SBH, Ishibashi K, et al. Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis. Am J Physiol Cell Physiol. 2009;297(6):C1368-78.
Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016;22(44):9694-705.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS. Pancreatic cancer: a review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 2018;24(43):4846-61.
Luchini C, Capelli P, Scarpa A. Pancreatic ductal adenocarcinoma and its variants. Surg Pathol Clin. 2016;9(4):547-60.
Huang X, Huang L, Shao M. Aquaporin 3 facilitates tumor growth in pancreatic cancer by modulating mTOR signaling. Biochem Biophys Res Commun. 2017;486(4):1097-102.
Magouliotis DE, Tasiopoulou VS, Dimas K, Sakellaridis N, Svokos KA, Svokos AA, et al. Transcriptomic analysis of the Aquaporin (AQP) gene family interactome identifies a molecular panel of four prognostic markers in patients with pancreatic ductal adenocarcinoma. Pancreatology. 2019;19(3):436-42.
Zou W, Yang Z, Li D, Liu Z, Zou Q, Yuan Y. AQP1 and AQP3 expression are associated with severe symptoms and poor-prognosis of the pancreatic ductal adenocarcinoma. Appl Immunohistochem Mol Morphol. 2019;27(1):40-7.
Jung HJ, Jang HJ, Kwon TH. Aquaporins implicated in the cell proliferation and the signaling pathways of cell stemness. Biochimie. 2021;188:52-60.
Galan-Cobo A, Ramirez-Lorca R, Serna A, Echevarria M. Overexpression of AQP3 modifies the cell cycle and the proliferation rate of mammalian cells in culture. PLoS One. 2015;10(9):e0137692.
Galan-Cobo A, Ramirez-Lorca R, Toledo-Aral JJ, Echevarria M. Aquaporin-1 plays important role in proliferation by affecting cell cycle progression. J Cell Physiol. 2016;231(1):243-56.
Woo J, Lee J, Kim MS, Jang SJ, Sidransky D, Moon C. The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochem Biophys Res Comm. 2008;367(2):291-8.
Jensen HH, Login FH, Park JY, Kwon TH, Nejsum LN. Immunohistochemical evalulation of activated Ras and Rac1 as potential downstream effectors of aquaporin-5 in breast cancer in vivo. Biochem Biophys Res Comm. 2017;493(3):1210-6.
Papadopoulos MC, Saadoun S, Verkman AS. Aquaporins and cell migration. Pflugers Arch. 2008;456(4):693-700.
Park E-J, Jung HJ, Choi H-J, Jang H-J, Park H-J, Nejsum LN, et al. Exosomes co-expressing AQP5-targeting miRNAs and IL-4 receptor-binding peptide inhibit the migration of human breast cancer cells. FASEB J. 2020;34(2):3379-98.
Liu W, Wang K, Gong K, Li X, Luo K. Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3. Mol Med Rep. 2012;6(3):607-10.
Xu H, Xu Y, Zhang W, Shen L, Yang L, Xu Z. Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells. J Exp Clin Cancer Res. 2011;30:86.
Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3):178-96.
Login FH, Jensen HH, Pedersen GA, Koffman JS, Kwon T-H, Parsons M, et al. Aquaporins differentially regulate cell-cell adhesion in MDCK cells. FASEB J. 2019;33(6):6980-94.
Login FH, Palmfeldt J, Cheah JS, Yamada S, Nejsum LN. Aquaporin-5 regulation of cell-cell adhesion proteins: an elusive "tail" story. Am J Physiol Cell Physiol 2021;320(3):C282-C92.
Edamana S, Login FH, Yamada S, Kwon TH, Nejsum LN. Aquaporin water channels as regulators of cell-cell adhesion proteins. Am J Physiol Cell Physiol. 2021;320(5):C771-7.
Monzani E, Bazzotti R, Perego C, La Porta CA. AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin. PLoS One. 2009;4(7):e6167.
Kim NH, Lee AY. Reduced aquaporin3 expression and survival of keratinocytes in the depigmented epidermis of vitiligo. J Invest Dermatol. 2010;130(9):2231-9.