Azithromycin versus Amoxicillin and Malarial Parasitemia among Children with Uncomplicated Severe Acute Malnutrition: A Randomized Controlled Trial.
Journal
The American journal of tropical medicine and hygiene
ISSN: 1476-1645
Titre abrégé: Am J Trop Med Hyg
Pays: United States
ID NLM: 0370507
Informations de publication
Date de publication:
27 09 2021
27 09 2021
Historique:
received:
26
05
2021
accepted:
11
08
2021
pubmed:
29
9
2021
medline:
25
2
2022
entrez:
28
9
2021
Statut:
epublish
Résumé
Antibiotics are recommended by the WHO as part of the management of uncomplicated severe acute malnutrition in children. We evaluated whether azithromycin, an antibiotic with antimalarial properties, improved malarial parasitemia outcomes in children with severe acute malnutrition compared with amoxicillin, an antibiotic commonly used for severe acute malnutrition that does not have antimalarial properties. Total of 301 children were randomized (1:1) to a single oral dose of azithromycin or a 7-day course of amoxicillin and followed for 8 weeks. We found no significant evidence that children receiving azithromycin had improved parasitemia outcomes relative to amoxicillin. Although azithromycin may have advantages over amoxicillin in terms of dosing and administration for uncomplicated severe acute malnutrition, it may not yield additional benefit for malaria outcomes.
Identifiants
pubmed: 34583344
doi: 10.4269/ajtmh.21-0595
pmc: PMC8733515
doi:
Substances chimiques
Anti-Infective Agents
0
Amoxicillin
804826J2HU
Azithromycin
83905-01-5
Banques de données
ClinicalTrials.gov
['NCT03568643']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-355Subventions
Organisme : NICHD NIH HHS
ID : R21 HD100932
Pays : United States
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