DNA methylation patterns in T lymphocytes are generally stable in human pregnancies but CD3 methylation is associated with perinatal psychiatric symptoms.
Anxiety
DNA methylation
Depression
Epigenetics
Immunity
Pregnancy
Stress
T cell
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
28
01
2020
accepted:
31
01
2020
entrez:
30
9
2021
pubmed:
18
2
2020
medline:
18
2
2020
Statut:
epublish
Résumé
To determine whether DNA methylation patterns in genes coding for selected T-lymphocyte proteins are associated with perinatal psychiatric distress or with complications of pregnancy. T lymphocyte DNA was obtained from pregnant women across three time points in pregnancy and the postpartum period and epigenetic patterns were assessed using Illumina 450 K Methylation Beadchips. Seven selected genes critical for T cell function were analyzed for methylation changes during pregnancy and for associations of methylation patterns with psychiatric distress or with pregnancy complications, with particular attention paid to spatial aggregations of methyl groups, termed 'hotspots,' within the selected genes. In the candidate gene approach, DNA methylation density within a single cluster of 9 contiguous CpG loci within the Despite the need for tolerating the fetal hemi-allograft, overall DNA methylation patterns in T lymphocytes are generally stable over the mid to late course of human pregnancies and postpartum. However, site-specific changes in DNA methylation density in
Identifiants
pubmed: 34589835
doi: 10.1016/j.bbih.2020.100044
pii: S2666-3546(20)30009-0
pmc: PMC8474679
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100044Subventions
Organisme : NIMH NIH HHS
ID : R01 MH092580
Pays : United States
Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors report no financial relationships with commercial interests.
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