Glycosylated constituents isolated from the trunk of Abies holophylla and their anti-inflammatory and neurotrophic activity.

Abies Anti-Inflammatory Agents / pharmacology Phenols Plant Extracts
Abies holophylla Anti-neuroinflammation Glycosylated natural products Neurotrophic effect Pinaceae

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 01 06 2021
revised: 17 09 2021
accepted: 17 09 2021
pubmed: 1 10 2021
medline: 16 11 2021
entrez: 30 9 2021
Statut: ppublish

Résumé

Eleven previously undescribed glycosylated compounds with phenolic (abeoside A-F), monoterpenyl (abeoside G and H), or 2-heptanyl (abeoside I-K) aglycone, and twenty one reported compounds were isolated from the trunk of Abies holophylla. The structures of the previously undescribed compounds were elucidated on the basis of the conventional NMR and HRMS data analysis, and the absolute configuration of sugar units were assigned by chiral derivatization and LC-MS analysis. All the isolated compounds were evaluated for their anti-neuroinflammatory and neurotrophic activities. Among the evaluated compounds, twelve compounds including abeoside A, B, E, G, H, J, and K exhibited strong anti-neuroinflammatory activities with IC

Identifiants

DOI: 10.1016/j.phytochem.2021.112962 PMID: 34592513
pubmed: 34592513
pii: S0031-9422(21)00311-3
doi: 10.1016/j.phytochem.2021.112962
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Phenols 0
Plant Extracts 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112962

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Tae Hyun Lee (TH)

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: thlee16@skku.edu.

Lalita Subedi (L)

Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea. Electronic address: subedilali@gmail.com.

Young Jun Ha (YJ)

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: yjha970220@skku.edu.

Gyuri Moon (G)

Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: mooniduni@skku.edu.

Sun Yeou Kim (SY)

Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea. Electronic address: sunnykim@gachon.ac.kr.

Chung Sub Kim (CS)

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: chungsub.kim@skku.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Pinales › Pinaceae › Abies › Glycosylated constituents isolated from the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Glycosylated constituents isolated from the...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Glycosylated constituents isolated from the...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Glycosylated constituents isolated from the...