Hydrogel Formation with Enzyme-Responsive Cyclic Peptides.

Hydrogels Peptides, Cyclic / chemistry Tissue Engineering Tissue Scaffolds
Enzyme-responsive Hydrogels Injectable Macrocycles Minimally invasive Proteolytic cleavage Self-assembling peptides Steric constraint Tissue engineering

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2022
Historique:
entrez: 1 10 2021
pubmed: 2 10 2021
medline: 6 1 2022
Statut: ppublish

Résumé

Self-assembling peptides (SAPs), which form hydrogels through physical cross-linking of soluble structures, are an intriguing class of materials that have been applied as tissue engineering scaffolds and drug delivery vehicles. For feasible application of these tissue mimetics via minimally invasive delivery, their bulk mechanical properties must be compatible with current delivery strategies. However, injectable SAPs which possess shear-thinning capacity, as well as the ability to reassemble after cessation of shearing can be technically challenging to generate. Many SAPs either clog the high-gauge needle/catheter at high concentration during delivery or are incapable of reassembly following delivery. In this chapter, we provide a detailed protocol for topological control of enzyme-responsive peptide-based hydrogels that enable the user to access both advantages. These materials are formulated as sterically constrained cyclic peptide progelators to temporarily disrupt self-assembly during injection-based delivery, which avoids issues with clogging of needles and catheters as well as nearby vasculature. Proteolytic cleavage by enzymes produced at the target tissue induces progelator linearization and hydrogelation. The scope of this approach is demonstrated by their ability to flow through a catheter without clogging and activated gelation upon exposure to target enzymes.

Identifiants

DOI: 10.1007/978-1-0716-1689-5_23 PMID: 34596862
pubmed: 34596862
doi: 10.1007/978-1-0716-1689-5_23
doi:

Substances chimiques

Hydrogels 0
Peptides, Cyclic 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

427-448

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL139001
Pays : United States

Informations de copyright

© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Andrea S Carlini (AS)

Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Department of Materials Science & Engineering, Northwestern University, Evanston, IL, USA.
Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Department of Pharmacology, Northwestern University, Evanston, IL, USA.
International Institute for Nanotechnology, Northwestern University, Evanston, IL, USA.
Simpson Querrey Institute, Northwestern University, Evanston, IL, USA.

Mary F Cassidy (MF)

Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Department of Materials Science & Engineering, Northwestern University, Evanston, IL, USA.
Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Department of Pharmacology, Northwestern University, Evanston, IL, USA.
International Institute for Nanotechnology, Northwestern University, Evanston, IL, USA.
Simpson Querrey Institute, Northwestern University, Evanston, IL, USA.

Nathan C Gianneschi (NC)

Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA. nathan.gianneschi@northwestern.edu.
Department of Materials Science & Engineering, Northwestern University, Evanston, IL, USA. nathan.gianneschi@northwestern.edu.
Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA. nathan.gianneschi@northwestern.edu.
Department of Pharmacology, Northwestern University, Evanston, IL, USA. nathan.gianneschi@northwestern.edu.
International Institute for Nanotechnology, Northwestern University, Evanston, IL, USA. nathan.gianneschi@northwestern.edu.
Simpson Querrey Institute, Northwestern University, Evanston, IL, USA. nathan.gianneschi@northwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Hydrogel Formation with Enzyme-Responsive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Hydrogel Formation with Enzyme-Responsive...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Ingénierie tissulaire › Hydrogel Formation with Enzyme-Responsive...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Structures d'échafaudage tissulaires › Hydrogel Formation with Enzyme-Responsive...