Intra-Articular Administration of a Synthetic Lubricin in Canine Stifles.

 The aim of this study was to evaluate the functional, systemic, synovial and articular changes after intra-articular administration of a synthetic lubricin within healthy canine stifles.  A prospective randomized blinded placebo-controlled study composed of 10 dogs equally divided into either a treatment group (intra-articular synthetic lubricin injection,  No significant differences between the treatment group and control group were identified with regard to baseline patient parameters. No clinically significant orthopaedic examination abnormalities, gait abnormalities, biochemical alterations, joint fluid alterations or histopathological alterations were identified over the course of the study.  The synthetic lubricin studied herein is both biocompatible and safe for a single administration within the canine stifle joint. Further research is necessary to evaluate the clinical efficacy of the synthetic lubricin in canine osteoarthritic joints.

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Déclaration de conflit d'intérêts

D.P. is listed as an inventor on various patents assigned to Cornell University that are associated with materials disclosed in this manuscript. There is no financial or other conflict of interest of any author related to a company or product used in the report. This study was never presented at any meetings.