Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABA
GABAB receptor
GIRK channel
baclofen
sensory neurons
α-conotoxin
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
25
08
2021
received:
07
03
2021
accepted:
30
08
2021
pubmed:
3
10
2021
medline:
15
3
2022
entrez:
2
10
2021
Statut:
ppublish
Résumé
Activation of GIRK channels via G protein-coupled GABA The effects of analgesic α-conotoxins, Vc1.1, RgIA, and PeIA, were investigated on inwardly-rectifying K Analgesic α-conotoxins Vc1.1, RgIA, and PeIA potentiate inwardly-rectifying K This is the first report of GIRK channel potentiation via allosteric α-conotoxin Vc1.1-GABA
Sections du résumé
BACKGROUND AND PURPOSE
Activation of GIRK channels via G protein-coupled GABA
EXPERIMENTAL APPROACH
The effects of analgesic α-conotoxins, Vc1.1, RgIA, and PeIA, were investigated on inwardly-rectifying K
KEY RESULTS
Analgesic α-conotoxins Vc1.1, RgIA, and PeIA potentiate inwardly-rectifying K
CONCLUSIONS AND IMPLICATIONS
This is the first report of GIRK channel potentiation via allosteric α-conotoxin Vc1.1-GABA
Substances chimiques
Analgesics
0
Calcium Channels, N-Type
0
Conotoxins
0
G Protein-Coupled Inwardly-Rectifying Potassium Channels
0
Receptors, GABA-B
0
Baclofen
H789N3FKE8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-198Informations de copyright
© 2021 The British Pharmacological Society.
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