Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains.
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Isoxazoles
/ chemistry
Models, Molecular
Molecular Structure
Piperidines
/ chemical synthesis
Structure-Activity Relationship
Triazoles
/ chemical synthesis
BRET (Bioluminescence Resonance Energy Transfer)
Bcl-xL (B-cell lymphoma-extra large)
Cancer
Molecular modelling
PUMA (p53 upregulated modulator of apoptosis)
Protein-protein interactions
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
15 11 2021
15 11 2021
Historique:
received:
06
08
2021
revised:
17
09
2021
accepted:
25
09
2021
pubmed:
4
10
2021
medline:
8
1
2022
entrez:
3
10
2021
Statut:
ppublish
Résumé
A small library of new piperidine-triazole hybrids with 3-aryl isoxazole side chains has been designed and synthesized. Their cytotoxicity against a panel of seven cancer cell lines has been established. For the most promising compound, an IC
Identifiants
pubmed: 34601029
pii: S0960-894X(21)00617-X
doi: 10.1016/j.bmcl.2021.128390
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Isoxazoles
0
Piperidines
0
Triazoles
0
piperidine
67I85E138Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
128390Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.