Synthesis, characterization and biological evaluation of indomethacin derived thioureas as purinergic (P2Y
Astrocytoma cells
Ca(+2) flux
Indomethacin
Molecular docking
P2Y receptor antagonist
Thiourea
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
08
06
2021
revised:
09
08
2021
accepted:
15
09
2021
pubmed:
4
10
2021
medline:
5
1
2022
entrez:
3
10
2021
Statut:
ppublish
Résumé
G-protein-coupled receptors for extracellular nucleotides are known as P2Y receptors and are made up of eight members that are encoded by distinct genes and can be classified into two classes based on their affinity for specific G-proteins. P2Y receptor modulators have been studied extensively, but only a few small-molecule P2Y receptor antagonists have been discovered so far and approved by drug agencies. Derivatives of indole carboxamide have been identified as P2Y
Identifiants
pubmed: 34601296
pii: S0045-2068(21)00755-0
doi: 10.1016/j.bioorg.2021.105378
pii:
doi:
Substances chimiques
Purinergic Antagonists
0
Receptors, Purinergic
0
Thiourea
GYV9AM2QAG
Indomethacin
XXE1CET956
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105378Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.