Could β-Lactam Antibiotics Block Humoral Immunity?
ARTEMIS
SNM1
V(D)J recombination
cephalosporin
human metallo β-lactamase
immunity
metallo β-lactamase
β-lactam antibiotics
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
03
2021
accepted:
26
08
2021
entrez:
4
10
2021
pubmed:
5
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
It has been reported that treatment with β-lactam antibiotics induces leukopenia and candidemia, worsens the clinical response to anticancer immunotherapy and decreases immune response to vaccination. β-lactamases can cleave β-lactam antibiotics by blocking their activity. Two distincts superfamilies of β-lactamases are described, the serine β-lactamases and the zinc ion dependent metallo-β-lactamases. In human, 18 metallo-β-lactamases encoding genes (hMBLs) have been identified. While the physiological role of most of them remains unknown, it is well established that the SNM1A, B and C proteins are involved in DNA repair. The SNM1C/Artemis protein is precisely associated in the V(D)J segments rearrangement, that leads to immunoglobulin (Ig) and T-cell receptor variable regions, which have a crucial role in the immune response. Thus in humans, SNM1C/Artemis mutation is associated with severe combined immunodeficiency characterized by hypogammaglobulinemia deficient cellular immunity and opportunistic infections. While catalytic site of hMBLs and especially that of the SNM1 family is highly conserved
Identifiants
pubmed: 34603278
doi: 10.3389/fimmu.2021.680146
pmc: PMC8480522
doi:
Substances chimiques
Anti-Bacterial Agents
0
DNA-Binding Proteins
0
Immunosuppressive Agents
0
beta-Lactams
0
DCLRE1C protein, human
EC 3.1.-
Endonucleases
EC 3.1.-
Exodeoxyribonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
680146Informations de copyright
Copyright © 2021 Melenotte, Pontarotti, Pinault, Mège, Devaux and Raoult.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Microbiol. 2013 May 22;4:128
pubmed: 23734147
ACS Chem Neurosci. 2017 Oct 18;8(10):2132-2138
pubmed: 28783953
Cell. 1978 Sep;15(1):1-14
pubmed: 100225
Am J Med. 1999 Jan;106(1):44-9
pubmed: 10320116
Ann N Y Acad Sci. 2003 Apr;987:150-7
pubmed: 12727634
FEBS Lett. 1996 May 6;385(3):197-200
pubmed: 8647250
FEBS Lett. 2001 Aug 10;503(1):1-6
pubmed: 11513844
Pediatr Allergy Immunol. 2019 Sep;30(6):668-671
pubmed: 30947362
Front Microbiol. 2017 Sep 19;8:1775
pubmed: 28974947
Cell Host Microbe. 2020 Aug 12;28(2):169-179
pubmed: 32791110
Lancet Infect Dis. 2014 Aug;14(8):742-750
pubmed: 25022435
Cell. 2019 Sep 5;178(6):1313-1328.e13
pubmed: 31491384
FEBS J. 2011 Apr;278(8):1252-63
pubmed: 21299838
Pediatrics. 2014 Aug;134(2):e362-72
pubmed: 25002669
Immunobiology. 2016 Sep;221(9):994-1000
pubmed: 27256989
Cell Host Microbe. 2018 May 9;23(5):653-660.e5
pubmed: 29746836
Nature. 1983 Apr 14;302(5909):575-81
pubmed: 6300689
J Clin Immunol. 2010 Mar;30(2):314-20
pubmed: 19967552
BMC Vet Res. 2015 Oct 22;11:268
pubmed: 26493336
J Biol Chem. 2020 Aug 28;295(35):12368-12377
pubmed: 32576658
Annu Rev Microbiol. 2011;65:455-78
pubmed: 21740228
Blood. 2003 Feb 15;101(4):1446-52
pubmed: 12406895
Trends Biochem Sci. 2016 Apr;41(4):338-355
pubmed: 26805042
Ann Oncol. 2018 Jun 1;29(6):1437-1444
pubmed: 29617710
BMC Cancer. 2019 Nov 12;19(1):1100
pubmed: 31718585
Pediatr Int. 2019 Sep;61(9):929-931
pubmed: 31393046
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3463-E3470
pubmed: 29581252
DNA Repair (Amst). 2009 Feb 1;8(2):202-8
pubmed: 19022407
ACS Infect Dis. 2020 Nov 13;6(11):3064-3075
pubmed: 33118347
PLoS One. 2016 Oct 31;11(10):e0165346
pubmed: 27798663
Nature. 1980 Aug 14;286(5774):676-83
pubmed: 6774258
Am J Perinatol. 2013 Aug;30(7):589-94
pubmed: 23277386
Nat Commun. 2021 May 7;12(1):2560
pubmed: 33963193
Mol Immunol. 2013 Dec;56(4):354-7
pubmed: 23911390
Immunity. 2014 Sep 18;41(3):478-492
pubmed: 25220212
Cell. 2001 Apr 20;105(2):177-86
pubmed: 11336668
Gut Microbes. 2018 Mar 4;9(2):93-101
pubmed: 28891751
J Clin Immunol. 2019 Jan;39(1):81-89
pubmed: 30607663
Pediatrics. 2006 Jan;117(1):84-92
pubmed: 16396864
Int J Mol Sci. 2020 Aug 29;21(17):
pubmed: 32872436
Blood. 2014 Jul 24;124(4):590-7
pubmed: 24948657
Annu Rev Immunol. 2000;18:495-527
pubmed: 10837067
Life (Basel). 2020 Nov 14;10(11):
pubmed: 33202677
Cell. 2002 Mar 22;108(6):781-94
pubmed: 11955432
Lancet Infect Dis. 2011 May;11(5):381-93
pubmed: 21530894
J Biol Chem. 2014 Mar 14;289(11):7825-34
pubmed: 24500713
Hum Genet. 2003 Apr;112(4):348-52
pubmed: 12592555
J Mol Biol. 2019 Aug 23;431(18):3472-3500
pubmed: 30959050
Trends Genet. 1996 Apr;12(4):150-5
pubmed: 8901420
MAbs. 2020 Jan-Dec;12(1):1729683
pubmed: 32097086
Chem Commun (Camb). 2016 May 10;52(40):6727-30
pubmed: 27121860
Diagn Microbiol Infect Dis. 2019 Sep;95(1):80-83
pubmed: 31129007
Sci Rep. 2020 Dec 10;10(1):21685
pubmed: 33303919
Front Immunol. 2018 Dec 21;9:2956
pubmed: 30627128
J Immunol. 2002 Jun 15;168(12):6323-9
pubmed: 12055248
JAMA Oncol. 2019 Dec 1;5(12):1774-1778
pubmed: 31513236
Immunol Rev. 2004 Aug;200:142-55
pubmed: 15242402
Dev Comp Immunol. 2017 Mar;68:69-78
pubmed: 27884707
Infect Immun. 2000 Oct;68(10):5690-5
pubmed: 10992472
Cell. 2019 Mar 7;176(6):1340-1355.e15
pubmed: 30799037
Science. 2015 Nov 27;350(6264):1079-84
pubmed: 26541610
Science. 2018 Jan 5;359(6371):91-97
pubmed: 29097494
J Mol Biol. 2014 Jun 26;426(13):2442-56
pubmed: 24769192
Curr Drug Targets. 2016;17(9):1029-50
pubmed: 26424398
Environ Mol Mutagen. 2010 Jul;51(6):635-45
pubmed: 20175117
Nucleic Acids Res. 2002 Aug 15;30(16):3592-601
pubmed: 12177301
Prenat Diagn. 2002 Sep;22(9):763-8
pubmed: 12224067
Sci Rep. 2019 Aug 21;9(1):12173
pubmed: 31434986
Adv Immunol. 2001;78:169-232
pubmed: 11432204
Sci Rep. 2017 Feb 21;7:43035
pubmed: 28220870
Arch Dermatol. 1999 Aug;135(8):927-31
pubmed: 10456341
Sci Rep. 2017 Jun 2;7(1):2722
pubmed: 28578431
PLoS One. 2020 Oct 30;15(10):e0241557
pubmed: 33126240
Appl Environ Microbiol. 1993 Oct;59(10):3339-49
pubmed: 7504430
J Exp Med. 2004 Feb 2;199(3):315-21
pubmed: 14744996
Biochem Pharmacol. 2007 Dec 15;74(12):1686-701
pubmed: 17597585
Chemotherapy. 1986;32(5):464-7
pubmed: 3757588
Science. 2013 Nov 22;342(6161):967-70
pubmed: 24264989
Cell. 2002 Apr;109 Suppl:S45-55
pubmed: 11983152
J Infect Dis. 2017 Jan 1;215(1):34-41
pubmed: 27803175
Chemotherapy. 1993 Jul-Aug;39(4):278-85
pubmed: 8325130
Nucleic Acids Res. 2021 Sep 20;49(16):9310-9326
pubmed: 34387696
Hum Mol Genet. 2015 Dec 20;24(25):7361-72
pubmed: 26476407