Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance.

Antimalarials / pharmacology Artemisinins / pharmacology BTB-POZ Domain Drug Resistance / genetics Mutation Plasmodium falciparum / drug effects Protozoan Proteins / genetics
BTB/POZ domain K13 mutation artemisinin resistance malaria

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
18 01 2022
Historique:
pubmed: 5 10 2021
medline: 23 3 2022
entrez: 4 10 2021
Statut: ppublish

Résumé

Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta-propeller domain of the Plasmodium falciparum

Identifiants

DOI: 10.1128/AAC.01320-21 PMID: 34606334 PMC: PMC8765297
pubmed: 34606334
doi: 10.1128/AAC.01320-21
pmc: PMC8765297
doi:

Substances chimiques

Antimalarials 0
Artemisinins 0
Protozoan Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0132021

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI109023
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI106711
Pays : United States

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Auteurs

Lucie Paloque (L)

LCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.
MAAP, New Antimalarial Molecules and Pharmacological Approaches, Toulouse, France.
Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
ORCID: 0000-0003-0359-3959

Romain Coppée (R)

Université de Paris, MERIT, IRD, Paris, France.

Barbara H Stokes (BH)

Department of Microbiology and Immunology, Department of Medicine, Columbia Universitygrid.239585.0grid.21729.3f Irving Medical Center, New York, New York, USA.

Nina F Gnädig (NF)

Department of Microbiology and Immunology, Department of Medicine, Columbia Universitygrid.239585.0grid.21729.3f Irving Medical Center, New York, New York, USA.

Karamoko Niaré (K)

Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

Jean-Michel Augereau (JM)

LCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.
MAAP, New Antimalarial Molecules and Pharmacological Approaches, Toulouse, France.
Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.

David A Fidock (DA)

Department of Microbiology and Immunology, Department of Medicine, Columbia Universitygrid.239585.0grid.21729.3f Irving Medical Center, New York, New York, USA.
Division of Infectious Diseases, Department of Medicine, Columbia Universitygrid.239585.0grid.21729.3f Irving Medical Center, New York, New York, USA.

Jérôme Clain (J)

Université de Paris, MERIT, IRD, Paris, France.
Centre National de Référence du Paludisme, Laboratoire de Parasitologie, Hôpital Bichat-Claude Bernard, HUPNVS, APHP, Paris, France.

Françoise Benoit-Vical (F)

LCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.
MAAP, New Antimalarial Molecules and Pharmacological Approaches, Toulouse, France.
Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
ORCID: 0000-0002-9468-4823

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Mutation in the Plasmodium falciparum BTB/POZ...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Mutation in the Plasmodium falciparum BTB/POZ...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Motifs et domaines d'intéraction protéique › Domaine BTB-POZ › Mutation in the Plasmodium falciparum BTB/POZ...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Mutation in the Plasmodium falciparum BTB/POZ...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation in the Plasmodium falciparum BTB/POZ...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Mutation in the Plasmodium falciparum BTB/POZ...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › Mutation in the Plasmodium falciparum BTB/POZ...