Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?
Antigens, Neoplasm
/ metabolism
Benzaldehydes
/ chemical synthesis
Binding Sites
/ drug effects
Carbonic Anhydrase IX
/ antagonists & inhibitors
Carbonic Anhydrase Inhibitors
/ chemical synthesis
Carbonic Anhydrases
/ metabolism
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Design
Humans
Molecular Docking Simulation
Molecular Structure
Structure-Activity Relationship
Vanillin
carbonic anhydrase
enones
enzyme inhibitors
molecular docking
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
5
10
2021
pubmed:
6
10
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
New
Identifiants
pubmed: 34607524
doi: 10.1080/14756366.2021.1982933
pmc: PMC8510595
doi:
Substances chimiques
Antigens, Neoplasm
0
Benzaldehydes
0
Carbonic Anhydrase Inhibitors
0
vanillin
CHI530446X
CA9 protein, human
EC 4.2.1.1
Carbonic Anhydrase IX
EC 4.2.1.1
Carbonic Anhydrases
EC 4.2.1.1
carbonic anhydrase XII
EC 4.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2118-2127Références
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