Acute and sustained increase in endothelial biomarkers in COVID-19.

Biomarkers COVID-19 Hospital Mortality Hospitalization Humans Intensive Care Units
COVID-19 pneumonia respiratory infection viral infection

Journal

Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353

Informations de publication

Date de publication:
04 2022
Historique:
received: 21 12 2020
accepted: 15 09 2021
pubmed: 6 10 2021
medline: 25 3 2022
entrez: 5 10 2021
Statut: ppublish

Résumé

Endothelial injury is related to poor outcomes in respiratory infections yet little is known in relation to COVID-19. Performing a longitudinal analysis (on emergency department admission and post-hospitalisation follow-up), we evaluated endothelial damage via surrogate systemic endothelial biomarkers, that is, proadrenomedullin (proADM) and proendothelin, in patients with COVID-19. Higher proADM and/or proendothelin levels at baseline were associated with the most severe episodes and intensive care unit admission when compared with ward-admitted individuals and outpatients. Elevated levels of proADM or proendothelin at day 1 were associated with in-hospital mortality. High levels maintained after discharge were associated with reduced diffusing capacity.

Identifiants

DOI: 10.1136/thoraxjnl-2020-216797 PMID: 34607904
pubmed: 34607904
pii: thoraxjnl-2020-216797
doi: 10.1136/thoraxjnl-2020-216797
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

400-403

Informations de copyright

© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Raúl Méndez (R)

Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain mendez_rau@gva.es.
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.
ORCID: 0000-0001-6300-9836

Paula González-Jiménez (P)

Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.
Medicine, University of Valencia, Valencia, Spain.

Ana Latorre (A)

Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.

Mónica Piqueras (M)

Medicine, University of Valencia, Valencia, Spain.
Laboratory, La Fe University and Polytechnic Hospital, Valencia, Spain.

Leyre Bouzas (L)

Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.
Medicine, University of Valencia, Valencia, Spain.

Katheryn Yépez (K)

Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.
Medicine, University of Valencia, Valencia, Spain.

Ana Ferrando (A)

Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.
Medicine, University of Valencia, Valencia, Spain.

Enrique Zaldívar-Olmeda (E)

Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.
Medicine, University of Valencia, Valencia, Spain.

Antonio Moscardó (A)

Platelet Function Unit, Health Research Institute La Fe, Valencia, Spain.

Ricardo Alonso (R)

Laboratory, La Fe University and Polytechnic Hospital, Valencia, Spain.

Soledad Reyes (S)

Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.

Rosario Menéndez (R)

Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.
Medicine, University of Valencia, Valencia, Spain.
Center for Biomedical Research Network in Respiratory Diseases (CIBERES), Madrid, Spain.
ORCID: 0000-0002-3592-3839

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Acute and sustained increase in endothelial...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Acute and sustained increase in endothelial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Mortalité hospitalière › Acute and sustained increase in endothelial...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Hospitalisation › Acute and sustained increase in endothelial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acute and sustained increase in endothelial...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Unités hospitalières › Unités de soins intensifs › Acute and sustained increase in endothelial...