Opportunities for Understanding MS Mechanisms and Progression With MRI Using Large-Scale Data Sharing and Artificial Intelligence.

Algorithms Artificial Intelligence Humans Information Dissemination Magnetic Resonance Imaging Multiple Sclerosis / diagnostic imaging

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
23 11 2021
Historique:
received: 10 08 2020
accepted: 09 09 2021
pubmed: 6 10 2021
medline: 7 4 2022
entrez: 5 10 2021
Statut: ppublish

Résumé

Patients with multiple sclerosis (MS) have heterogeneous clinical presentations, symptoms, and progression over time, making MS difficult to assess and comprehend in vivo. The combination of large-scale data sharing and artificial intelligence creates new opportunities for monitoring and understanding MS using MRI. First, development of validated MS-specific image analysis methods can be boosted by verified reference, test, and benchmark imaging data. Using detailed expert annotations, artificial intelligence algorithms can be trained on such MS-specific data. Second, understanding disease processes could be greatly advanced through shared data of large MS cohorts with clinical, demographic, and treatment information. Relevant patterns in such data that may be imperceptible to a human observer could be detected through artificial intelligence techniques. This applies from image analysis (lesions, atrophy, or functional network changes) to large multidomain datasets (imaging, cognition, clinical disability, genetics). After reviewing data sharing and artificial intelligence, we highlight 3 areas that offer strong opportunities for making advances in the next few years: crowdsourcing, personal data protection, and organized analysis challenges. Difficulties as well as specific recommendations to overcome them are discussed, in order to best leverage data sharing and artificial intelligence to improve image analysis, imaging, and the understanding of MS.

Identifiants

DOI: 10.1212/WNL.0000000000012884 PMID: 34607924 PMC: PMC8610621
pubmed: 34607924
pii: WNL.0000000000012884
doi: 10.1212/WNL.0000000000012884
pmc: PMC8610621
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

989-999

Subventions

Organisme : Wellcome Trust
ID : 215573/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203139/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT203148/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT213038/Z/18/Z
Pays : United Kingdom

Investigateurs

Nicola de Stefano (N)
Jaume Sastre- Garriga (JS)
Olga Ciccarelli (O)
Christian Enzinger (C)
Massimo Filippi (M)
Claudio Gasperini (C)
Ludwig Kappos (L)
Jacqueline Palace (J)
Alex Rovira (A)
Tarek Yousry (T)

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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Auteurs

Hugo Vrenken (H)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK. h.vrenken@amsterdamumc.nl.
ORCID: 0000-0001-9106-1172

Mark Jenkinson (M)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.

Dzung L Pham (DL)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.

Charles R G Guttmann (CRG)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.

Deborah Pareto (D)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.

Michel Paardekooper (M)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.

Alexandra de Sitter (A)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.

Maria A Rocca (MA)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.
ORCID: 0000-0003-2358-4320

Viktor Wottschel (V)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.
ORCID: 0000-0002-2902-2268

M Jorge Cardoso (MJ)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.

Frederik Barkhof (F)

From the MS Center Amsterdam (H.V., A.d.S., V.W.), Amsterdam Neuroscience, Department of Radiology and Nuclear Medicine, Amsterdam UMC (M.P.), the Netherlands; Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB (M.J.), Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford, UK; Human Imaging and Image Processing Core (D.L.P.), Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD; Center for Neurological Imaging (C.R.G.G.), Department of Radiology, Brigham and Women's Hospital, Boston, MA; Section of Neuroradiology (Department of Radiology) (D.P.), Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University Barcelona, Spain; Neuroimaging Research Unit (M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; AMIGO (M.J.C.), School of Biomedical Engineering and Imaging Sciences, King's College London; and Institutes of Neurology & Healthcare Engineering (F.B.), UCL London, UK.
ORCID: 0000-0003-3543-3706

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Opportunities for Understanding MS Mechanisms...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Intelligence artificielle › Opportunities for Understanding MS Mechanisms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Opportunities for Understanding MS Mechanisms...
questionsmedicales.fr › Sciences de l'information › Communication › Diffusion de l'information › Opportunities for Understanding MS Mechanisms...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Opportunities for Understanding MS Mechanisms...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Opportunities for Understanding MS Mechanisms...