Comparison of General and Liver-Specific Prognostic Scores in Their Ability to Predict Mortality in Cirrhotic Patients Admitted to the Intensive Care Unit.
Journal
Canadian journal of gastroenterology & hepatology
ISSN: 2291-2797
Titre abrégé: Can J Gastroenterol Hepatol
Pays: Egypt
ID NLM: 101623613
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
03
2021
revised:
21
06
2021
accepted:
01
09
2021
entrez:
5
10
2021
pubmed:
6
10
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Acute Physiology and Chronic Health Evaluation (APACHE) II and III and Sequential Organ Failure Assessment (SOFA) are prognostic scores commonly used in the intensive care unit (ICU). Their accuracy in predicting mortality has not been adequately evaluated in comparison to prognostic scores commonly used in critically ill cirrhotic patients with acute decompensation (AD) or acute-on-chronic liver failure (ACLF). This study was conducted to evaluate the performance of prognostic scores, including APACHE II, SOFA, Chronic Liver Failure Consortium (CLIF-C) SOFA, Child-Turcotte-Pugh (CPS), Model for End-Stage Liver Disease (MELD), MELD-Na, MELD to serum sodium ratio (MESO) index, CLIF-C organ failure (CLIF-C OF), CLIF-C ACLF, and CLIF-C AD scores, in predicting mortality of cirrhotic patients admitted to the ICU. Mortality was observed in 31% of the patients. Analysis of AUC revealed that CLIF-C OF (0.807) and CLIF-SOFA (0.776) had the best ability to predict mortality in all patients, but CLIF-C OF (0.749) had higher prognostic accuracy in patients with ACLF. CLIF-SOFA, SOFA, and CLIF-C AD had the highest AUC values in patients with AD, with no statistical difference ( When compared to other general or liver-specific prognostic scores, CLIF-C OF, CLIF-SOFA, SOFA, and CLIF-C AD have good accuracy to predict mortality in critically ill patients with cirrhosis and patients with AD. According to the clinical scenario, different scores should be used to provide prognosis to patients with cirrhosis in the ICU.
Identifiants
pubmed: 34608435
doi: 10.1155/2021/9953106
pmc: PMC8487366
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9953106Informations de copyright
Copyright © 2021 Pedro Paulo Costa e Silva et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Shock. 2011 Nov;36(5):445-50
pubmed: 21841535
J Intensive Care Soc. 2015 Aug;16(3):240
pubmed: 28979418
J Hepatol. 2012;56 Suppl 1:S13-24
pubmed: 22300462
Curr Opin Crit Care. 2013 Apr;19(2):154-60
pubmed: 23426137
Liver Transpl. 2007 Aug;13(8):1174-80
pubmed: 17663415
J Hepatol. 2015 Apr;62(4):831-40
pubmed: 25463539
Gastroenterology. 2006 May;130(6):1652-60
pubmed: 16697729
Clin Transplant. 2017 Dec;31(12):
pubmed: 28895204
J Hepatol. 2014 Feb;60(2):275-81
pubmed: 24128414
Liver Int. 2014 Nov;34(10):1496-503
pubmed: 24606193
Gastroenterology. 2013 Jun;144(7):1426-37, 1437.e1-9
pubmed: 23474284
N Engl J Med. 2020 May 28;382(22):2137-2145
pubmed: 32459924
BMC Infect Dis. 2021 May 26;21(1):483
pubmed: 34039297
Hepatology. 2001 Feb;33(2):464-70
pubmed: 11172350
Liver Int. 2007 May;27(4):498-506
pubmed: 17403190
Cancer. 1950 Jan;3(1):32-5
pubmed: 15405679
Hepatology. 2017 Jan;65(1):310-335
pubmed: 27786365
Ann Hepatol. 2012 Jan-Feb;11(1):90-5
pubmed: 22166566
J Hepatol. 2019 Jan;70(1):151-171
pubmed: 30266282
Dig Dis Sci. 2021 Jan 3;:
pubmed: 33389350
J Hepatol. 2018 Aug;69(2):406-460
pubmed: 29653741
Scand J Gastroenterol. 2017 Dec;52(12):1385-1390
pubmed: 28851246
Ann Intensive Care. 2017 Dec;7(1):33
pubmed: 28321803
Hepatology. 2001 Aug;34(2):255-61
pubmed: 11481609
Am J Epidemiol. 2011 Mar 15;173(6):676-82
pubmed: 21330339
Crit Care. 2018 Oct 10;22(1):254
pubmed: 30305132
World J Gastroenterol. 2017 Jul 28;23(28):5237-5245
pubmed: 28811718
J Hepatol. 2014 Nov;61(5):1038-47
pubmed: 24950482
Liver Transpl. 2016 Sep;22(9):1254-8
pubmed: 27228568
Clin Liver Dis (Hoboken). 2020 Sep 22;16(3):114-116
pubmed: 33005392
Am J Gastroenterol. 2014 Apr;109(4):554-62
pubmed: 24492755
Liver Transpl. 2005 Mar;11(3):336-43
pubmed: 15719386
Crit Care. 2010;14(2):207
pubmed: 20392287
J Hepatol. 2015 Apr;62(4):968-74
pubmed: 25638527
Crit Care Med. 2018 Nov;46(11):1783-1791
pubmed: 30106759
Br J Surg. 1973 Aug;60(8):646-9
pubmed: 4541913
Arq Gastroenterol. 2015 Dec;52 Suppl 1:55-72
pubmed: 26959806
J Crit Care. 2014 Oct;29(5):881.e7-13
pubmed: 24974049
Hepatology. 2019 Jan;69(1):258-269
pubmed: 30070381
J Hepatol. 2016 Mar;64(3):717-35
pubmed: 26519602
J Crit Care. 2016 Dec;36:234-239
pubmed: 27569253
Crit Care Med. 2010 Nov;38(11):2108-16
pubmed: 20802324
J Crit Care. 2014 Dec;29(6):1131.e1-6
pubmed: 25175945
Gastroenterology. 2010 Oct;139(4):1246-56, 1256.e1-5
pubmed: 20558165
Crit Care. 2008;12(6):R161
pubmed: 19091120
Hepatology. 2014 Jul;60(1):250-6
pubmed: 24677131
Aliment Pharmacol Ther. 2006 Aug 1;24(3):453-64
pubmed: 16886911
Biometrics. 1988 Sep;44(3):837-45
pubmed: 3203132
Ann Hepatol. 2012 Jul-Aug;11(4):513-8
pubmed: 22700633
J Hepatol. 2012 Jan;56(1):95-102
pubmed: 21835136
Aliment Pharmacol Ther. 2014 May;39(10):1180-93
pubmed: 24654740
J Clin Med. 2020 May 20;9(5):
pubmed: 32443729
Liver Int. 2015 May;35(5):1516-23
pubmed: 24840673
Liver Transpl. 2021 Feb;27(2):177-189
pubmed: 33025731