Plant casein kinases phosphorylate and destabilize a cyclin-dependent kinase inhibitor to promote cell division.
Journal
Plant physiology
ISSN: 1532-2548
Titre abrégé: Plant Physiol
Pays: United States
ID NLM: 0401224
Informations de publication
Date de publication:
05 10 2021
05 10 2021
Historique:
received:
10
05
2021
accepted:
27
05
2021
entrez:
5
10
2021
pubmed:
6
10
2021
medline:
1
3
2022
Statut:
ppublish
Résumé
Cell cycle is one of the most fundamentally conserved biological processes of plants and mammals. Casein kinase1s (CK1s) are critical for cell proliferation in mammalian cells; however, how CK1s coordinate cell division in plants remains unknown. Through genetic and biochemical studies, here we demonstrated that plant CK1, Arabidopsis (Arabidopsis thaliana) EL1-like (AELs), regulate cell cycle/division by modulating the stability and inhibitory effects of Kip-related protein6 (KRP6) through phosphorylation. Cytological analysis showed that AELs deficiency results in suppressed cell-cycle progression mainly due to the decreased DNA replication rate at S phase and increased period of G2 phase. AELs interact with and phosphorylate KRP6 at serines 75 and 109 to stimulate KRP6's interaction with E3 ligases, thus facilitating the KRP6 degradation through the proteasome. These results demonstrate the crucial roles of CK1s/AELs in regulating cell division through modulating cell-cycle rates and elucidate how CK1s/AELs regulate cell division by destabilizing the stability of cyclin-dependent kinase inhibitor KRP6 through phosphorylation, providing insights into the plant cell-cycle regulation through CK1s-mediated posttranslational modification.
Identifiants
pubmed: 34608955
pii: 6305969
doi: 10.1093/plphys/kiab284
pmc: PMC8491028
doi:
Substances chimiques
Arabidopsis Proteins
0
Carrier Proteins
0
KRP6 protein, Arabidopsis
0
AT2G25760 protein, Arabidopsis
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
917-930Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of American Society of Plant Biologists.
Références
Mol Cell Proteomics. 2007 Jul;6(7):1226-38
pubmed: 17426018
Adv Genet. 2011;74:175-230
pubmed: 21924978
Front Plant Sci. 2014 May 15;5:208
pubmed: 24860589
Plant Cell. 2017 Sep;29(9):2197-2213
pubmed: 28790150
Plant J. 1999 Nov;20(4):503-8
pubmed: 10607302
Nature. 2001 May 17;411(6835):342-8
pubmed: 11357141
PLoS One. 2009;4(3):e4780
pubmed: 19277118
Plant J. 2014 May;78(3):468-80
pubmed: 24635058
Annu Rev Plant Biol. 2003;54:63-92
pubmed: 14502985
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11528-11536
pubmed: 31097584
Plant Cell. 2013 Jul;25(7):2618-32
pubmed: 23897926
Plant Cell. 2006 Nov;18(11):3132-44
pubmed: 17098812
Nature. 2008 Oct 23;455(7216):1134-7
pubmed: 18948957
Plant Methods. 2010 Jan 28;6(1):5
pubmed: 20181034
Plant J. 1998 Dec;16(6):735-43
pubmed: 10069079
New Phytol. 2019 Feb;221(3):1345-1358
pubmed: 30267580
New Phytol. 2013 Jan;197(2):490-502
pubmed: 23253334
Plant J. 2013 Aug;75(3):515-25
pubmed: 23617622
Plant Cell. 2001 Jul;13(7):1653-68
pubmed: 11449057
Cell Signal. 2005 Jun;17(6):675-89
pubmed: 15722192
Plant Cell. 1999 Apr;11(4):509-22
pubmed: 10213774
Plant Cell. 2014 Jun 24;26(6):2633-2647
pubmed: 24963053
Cell Signal. 1998 Nov;10(10):699-711
pubmed: 9884021
Science. 2017 Apr 28;356(6336):
pubmed: 28450583
Plant Cell. 2008 Jun;20(6):1538-54
pubmed: 18552199
Front Oncol. 2014 May 19;4:96
pubmed: 24904820
Mol Plant. 2018 May 7;11(5):706-719
pubmed: 29505832
Sci Rep. 2016 Mar 29;6:23586
pubmed: 27021201
J Exp Bot. 2014 Jun;65(10):2703-14
pubmed: 24218325
Plant Cell Rep. 2007 Jul;26(7):861-72
pubmed: 17253089
Plant Cell. 2018 Jan;30(1):67-82
pubmed: 29255112
Annu Rev Genet. 2006;40:77-105
pubmed: 17094738
Plant Cell. 2009 Aug;21(8):2378-90
pubmed: 19717618
Plant J. 2013 Aug;75(4):642-55
pubmed: 23647236
Cell Rep. 2014 Dec 11;9(5):1692-1702
pubmed: 25464840
Plant Mol Biol. 2000 Aug;43(5-6):621-33
pubmed: 11089865
Nat Commun. 2017 May 11;8:15234
pubmed: 28492234
Annu Rev Plant Biol. 2003;54:235-64
pubmed: 14502991
Plant Physiol. 2008 Dec;148(4):1897-907
pubmed: 18945931
Front Plant Sci. 2017 May 04;8:686
pubmed: 28523006
Trends Plant Sci. 2012 Jun;17(6):332-40
pubmed: 22401845
Nature. 1997 Apr 3;386(6624):451-2
pubmed: 9087400
EMBO J. 2010 Jun 2;29(11):1916-27
pubmed: 20400938
Cells. 2019 May 27;8(5):
pubmed: 31137886
Nat Cell Biol. 1999 Jul;1(3):E73-9
pubmed: 10559915
Plant Cell. 2006 Apr;18(4):893-906
pubmed: 16517759
Genes (Basel). 2020 Mar 24;11(3):
pubmed: 32214028
Annu Rev Cell Dev Biol. 1997;13:261-91
pubmed: 9442875
Plant J. 2003 Oct;36(2):189-202
pubmed: 14535884
Nat Commun. 2017 May 11;8:15236
pubmed: 28492231
PLoS Genet. 2012;8(8):e1002847
pubmed: 22879821