Inflammasome activation in infected macrophages drives COVID-19 pathology.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
01 Apr 2022
01 Apr 2022
Historique:
pubmed:
7
10
2021
medline:
7
10
2021
entrez:
6
10
2021
Statut:
epublish
Résumé
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA, and sustained interferon (IFN) response all of which are recapitulated and required for pathology in the SARS-CoV-2 infected MISTRG6-hACE2 humanized mouse model of COVID-19 with a human immune system
Identifiants
pubmed: 34611663
doi: 10.1101/2021.09.27.461948
pmc: PMC8491846
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : K12 CA215110
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM142687
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Commentaires et corrections
Type : UpdateIn