Association of donor hepatitis C virus infection status and risk of BK polyomavirus viremia after kidney transplantation.
JC
clinical research
infection and infectious agents - viral: BK
infection and infectious agents - viral: hepatitis C
infectious disease
kidney transplantation
nephrology
polyoma
practice
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
01
08
2021
received:
12
02
2021
accepted:
03
09
2021
pubmed:
7
10
2021
medline:
5
4
2022
entrez:
6
10
2021
Statut:
ppublish
Résumé
Kidney transplantation (KT) from deceased donors with hepatitis C virus (HCV) into HCV-negative recipients has become more common. However, the risk of complications such as BK polyomavirus (BKPyV) remains unknown. We assembled a retrospective cohort at four centers. We matched recipients of HCV-viremic kidneys to highly similar recipients of HCV-aviremic kidneys on established risk factors for BKPyV. To limit bias, matches were within the same center. The primary outcome was BKPyV viremia ≥1000 copies/ml or biopsy-proven BKPyV nephropathy; a secondary outcome was BKPyV viremia ≥10 000 copies/ml or nephropathy. Outcomes were analyzed using weighted and stratified Cox regression. The median days to peak BKPyV viremia level was 119 (IQR 87-182). HCV-viremic KT was not associated with increased risk of the primary BKPyV outcome (HR 1.26, p = .22), but was significantly associated with the secondary outcome of BKPyV ≥10 000 copies/ml (HR 1.69, p = .03). One-year eGFR was similar between the matched groups. Only one HCV-viremic kidney recipient had primary graft loss. In summary, HCV-viremic KT was not significantly associated with the primary outcome of BKPyV viremia, but the data suggested that donor HCV might elevate the risk of more severe BKPyV viremia ≥10 000 copies/ml. Nonetheless, one-year graft function for HCV-viremic recipients was reassuring.
Identifiants
pubmed: 34613666
doi: 10.1111/ajt.16834
pmc: PMC8968853
mid: NIHMS1739835
pii: S1600-6135(22)08102-3
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
599-609Subventions
Organisme : NIAID NIH HHS
ID : K24 AI146137
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK070869
Pays : United States
Informations de copyright
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.
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