Fetal Estrogens are not Involved in Sex Determination But Critical for Early Ovarian Differentiation in Rabbits.
Animals
Anti-Mullerian Hormone
/ metabolism
Cell Differentiation
Cell Proliferation
Cytochrome P450 Family 19
/ metabolism
Estradiol
/ metabolism
Estrogens
/ metabolism
Female
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gonads
INDEL Mutation
Ovarian Follicle
/ physiology
Ovary
/ embryology
Ovulation
Phenotype
Rabbits
Sex Determination Processes
/ physiology
Sex Differentiation
/ physiology
Testosterone
/ metabolism
AROMATASE
CYP19A1
TALEN
ovary
rabbit
sex determination
Journal
Endocrinology
ISSN: 1945-7170
Titre abrégé: Endocrinology
Pays: United States
ID NLM: 0375040
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
received:
17
03
2021
pubmed:
7
10
2021
medline:
28
12
2021
entrez:
6
10
2021
Statut:
ppublish
Résumé
AROMATASE is encoded by the CYP19A1 gene and is the cytochrome enzyme responsible for estrogen synthesis in vertebrates. In most mammals, a peak of CYP19A1 gene expression occurs in the fetal XX gonad when sexual differentiation is initiated. To elucidate the role of this peak, we produced 3 lines of TALEN genetically edited CYP19A1 knockout (KO) rabbits that were devoid of any estradiol production. All the KO XX rabbits developed as females with aberrantly small ovaries in adulthood, an almost empty reserve of primordial follicles, and very few large antrum follicles. Ovulation never occurred. Our histological, immunohistological, and transcriptomic analyses showed that the estradiol surge in the XX fetal rabbit gonad is not essential to its determination as an ovary, or for meiosis. However, it is mandatory for the high proliferation and differentiation of both somatic and germ cells, and consequently for establishment of the ovarian reserve.
Identifiants
pubmed: 34614143
pii: 6382335
doi: 10.1210/endocr/bqab210
pmc: PMC8598387
pii:
doi:
Substances chimiques
Estrogens
0
Testosterone
3XMK78S47O
Estradiol
4TI98Z838E
Anti-Mullerian Hormone
80497-65-0
Cytochrome P450 Family 19
EC 1.14.14.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.
Références
J Cell Biol. 1970 Dec;47(3):577-84
pubmed: 5497539
J Reprod Fertil. 1996 Sep;108(1):115-22
pubmed: 8958837
Biol Reprod. 1980 Oct;23(3):577-82
pubmed: 6256013
J Dev Orig Health Dis. 2018 Oct;9(5):519-529
pubmed: 29909796
J Clin Res Pediatr Endocrinol. 2016 Jun 5;8(2):205-10
pubmed: 27086564
Reproduction. 2014 Aug;148(2):211-9
pubmed: 24859845
J Exp Zool. 2001 Dec 1;290(7):727-40
pubmed: 11748621
Endocrinology. 2017 Sep 1;158(9):3030-3041
pubmed: 28575219
Nature. 1990 Jul 19;346(6281):240-4
pubmed: 1695712
Hum Mol Genet. 2008 May 1;17(9):1278-91
pubmed: 18250097
Nature. 1978 Jul 13;274(5667):172-3
pubmed: 662014
Reprod Biol Endocrinol. 2011 Jan 11;9:2
pubmed: 21223560
Science. 1992 Jan 24;255(5043):467-70
pubmed: 1734525
Proc Natl Acad Sci U S A. 1975 Jan;72(1):298-300
pubmed: 1054506
Arch Biochem Biophys. 2017 May 15;622:47-58
pubmed: 28341248
J Mol Endocrinol. 2006 Jun;36(3):399-413
pubmed: 16720712
Cell. 2009 Dec 11;139(6):1130-42
pubmed: 20005806
Biol Reprod. 1983 Oct;29(3):791-8
pubmed: 6626655
J Clin Endocrinol Metab. 2012 Sep;97(9):E1649-57
pubmed: 22689696
PLoS One. 2013 Apr 08;8(4):e60451
pubmed: 23593221
Mol Pharmacol. 2014 Feb;85(2):290-300
pubmed: 24280011
Development. 2012 Dec 1;139(23):4461-72
pubmed: 23095882
Endocrinology. 2000 Jul;141(7):2614-23
pubmed: 10875266
J Endocr Soc. 2020 Mar 10;4(4):bvaa030
pubmed: 32318648
Eur J Biochem. 2001 Aug;268(16):4506-12
pubmed: 11502211
J Reprod Fertil. 1980 Nov;60(2):409-17
pubmed: 6448924
Vitam Horm. 2018;107:155-175
pubmed: 29544629
Science. 1978 Jan 13;199(4325):200-1
pubmed: 579477
Nature. 1999 Feb 4;397(6718):405-9
pubmed: 9989404
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6965-70
pubmed: 9618522
PLoS One. 2012;7(1):e29937
pubmed: 22253831
Sci Rep. 2020 Mar 19;10(1):4992
pubmed: 32193429
J Clin Res Pediatr Endocrinol. 2018 Mar 19;10(4):377-381
pubmed: 29553041
PLoS One. 2014 Sep 12;9(9):e106655
pubmed: 25216115
FEBS Lett. 2006 Jun 26;580(15):3715-20
pubmed: 16765952
Biol Reprod. 2014 Dec;91(6):153
pubmed: 25395674
Arch Pharm Res. 2018 Sep;41(9):885-897
pubmed: 29777358
Physiol Rev. 2007 Jan;87(1):1-28
pubmed: 17237341
Science. 1999 Dec 17;286(5448):2328-31
pubmed: 10600740
Anim Reprod Sci. 2010 Jan;117(1-2):24-33
pubmed: 19501990
Hum Reprod Update. 2016 Nov;22(6):709-724
pubmed: 27566840
Mol Cell Endocrinol. 2016 Sep 15;433:66-74
pubmed: 27256151
J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):181-5
pubmed: 11850223
Curr Biol. 2014 Feb 17;24(4):404-8
pubmed: 24485832
J Clin Endocrinol Metab. 1978 Sep;47(3):550-5
pubmed: 263310
Sex Dev. 2009;3(5):273-83
pubmed: 19844082
PLoS One. 2013;8(2):e55578
pubmed: 23409002
J Embryol Exp Morphol. 1966 Dec;16(3):591-607
pubmed: 5962701
J Steroid Biochem Mol Biol. 2015 Aug;152:89-100
pubmed: 25958048
Reprod Biol. 2014 Mar;14(1):3-8
pubmed: 24607249
Endocrinology. 1994 Jul;135(1):262-8
pubmed: 8013361
Dev Dyn. 2004 Dec;231(4):859-70
pubmed: 15517586
Biol Reprod. 2014 Sep;91(3):68
pubmed: 25078683
Reprod Fertil Dev. 2001;13(7-8):543-7
pubmed: 11999304
Endocrinology. 2022 Jan 1;163(1):
pubmed: 34614143
Int J Dev Biol. 1996 Jun;40(3):567-75
pubmed: 8840189
Sex Dev. 2017;11(5-6):275-279
pubmed: 29324451
Reproduction. 2001 May;121(5):685-95
pubmed: 11427156
Hum Mol Genet. 2008 May 1;17(9):1264-77
pubmed: 18250098
Nat Biotechnol. 2011 Aug 05;29(8):697-8
pubmed: 21822241
Sex Dev. 2008;2(3):152-66
pubmed: 18769075
Sex Dev. 2014;8(5):227-42
pubmed: 24577119
Gen Comp Endocrinol. 2010 Feb 1;165(3):352-66
pubmed: 19289125
J Endocrinol. 2019 Feb 1;240(2):215-228
pubmed: 30403655
Mol Cell Endocrinol. 2002 May 31;191(1):1-10
pubmed: 12044912
Mol Hum Reprod. 2007 May;13(5):317-22
pubmed: 17350964
Nat Genet. 2006 Nov;38(11):1304-9
pubmed: 17041600
Development. 2020 Feb 25;147(4):
pubmed: 32001442
Science. 2018 Jun 29;360(6396):1469-1473
pubmed: 29903884