Antenatal Mesenchymal Stromal Cell Extracellular Vesicle Therapy Prevents Preeclamptic Lung Injury in Mice.
bronchopulmonary dysplasia
exosomes
lung development
preeclampsia
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
pubmed:
7
10
2021
medline:
19
2
2022
entrez:
6
10
2021
Statut:
ppublish
Résumé
In preeclamptic pregnancies, a variety of intrauterine alterations lead to abnormal placentation, release of inflammatory and/or antiangiogenic factors, and subsequent fetal growth restriction with significant potential to cause a primary insult to the developing fetal lung. Thus, modulation of the maternal intrauterine environment may be a key therapeutic avenue to prevent preeclampsia-associated developmental lung injury. A biologic therapy of interest is mesenchymal stromal cell-derived extracellular vesicles (MEx), which we have previously shown to ameliorate preeclamptic physiology through intrauterine immunomodulation. To evaluate the therapeutic potential of MEx to improve developmental lung injury in experimental preeclampsia, using the heme oxygenase-1-null mouse (
Identifiants
pubmed: 34614384
doi: 10.1165/rcmb.2021-0307OC
pmc: PMC8803363
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-95Subventions
Organisme : NHLBI NIH HHS
ID : T32HL007633
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007633
Pays : United States
Organisme : National Institute of Child Health and Human Development
ID : T32HD098061
Organisme : NICHD NIH HHS
ID : T32 HD098061
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146128
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI134025
Pays : United States
Commentaires et corrections
Type : CommentIn
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