Antibiotics as immunomodulators: a potential pharmacologic approach for ARDS treatment.
Journal
European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391
Informations de publication
Date de publication:
31 Dec 2021
31 Dec 2021
Historique:
received:
11
04
2021
accepted:
02
07
2021
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
25
11
2021
Statut:
epublish
Résumé
First described in the mid-1960s, acute respiratory distress syndrome (ARDS) is a life-threatening form of respiratory failure with an overall mortality rate of approximately 40%. Despite significant advances in the understanding and treatment of ARDS, no substantive pharmacologic therapy has proven to be beneficial, and current management continues to be primarily supportive. Beyond their antibacterial activity, several antibiotics such as macrolides and tetracyclines exert pleiotropic immunomodulatory effects that might be able to rectify the dysregulated inflammatory response present in patients with ARDS. This review aims to provide an overview of preclinical and clinical studies that describe the immunomodulatory effects of antibiotics in ARDS. Moreover, the underlying mechanisms of their immunomodulatory properties will be discussed. Further studies are necessary to investigate their full therapeutic potential and to identify ARDS phenotypes which are most likely to benefit from their immunomodulatory effects.
Identifiants
pubmed: 34615700
pii: 30/162/210093
doi: 10.1183/16000617.0093-2021
pmc: PMC9489085
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Immunologic Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©The authors 2021.
Déclaration de conflit d'intérêts
Conflict of interest: A. Sauer has nothing to disclose. Conflict of interest: K. Peukert has nothing to disclose. Conflict of interest: C. Putensen has nothing to disclose. Conflict of interest: C. Bode has nothing to disclose.
Références
Crit Care. 2016 Sep 09;20:268
pubmed: 27608629
Mediators Inflamm. 2012;2012:528568
pubmed: 22761540
Eur Respir J. 2018 Aug 2;52(2):
pubmed: 29946009
Curr Mol Pharmacol. 2008 Jan;1(1):68-79
pubmed: 20021425
Exp Mol Pathol. 2012 Jun;92(3):287-95
pubmed: 22421441
Sci Rep. 2020 Oct 2;10(1):16377
pubmed: 33009444
Antimicrob Agents Chemother. 1999 Mar;43(3):697-8
pubmed: 10049293
J Pharmacol Exp Ther. 2010 Apr;333(1):81-90
pubmed: 20040578
Pulm Pharmacol Ther. 2010 Apr;23(2):97-106
pubmed: 19895898
Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2448-53
pubmed: 8637894
Can J Infect Dis. 2002 Jan;13(1):54-61
pubmed: 18159374
Antimicrob Agents Chemother. 2003 May;47(5):1614-20
pubmed: 12709330
Eur J Immunol. 2010 Mar;40(3):620-3
pubmed: 20201015
JAMA Netw Open. 2020 Apr 1;3(4):e203482
pubmed: 32324238
Cell. 2008 Apr 18;133(2):235-49
pubmed: 18423196
J Immunol. 2004 Jun 15;172(12):7603-9
pubmed: 15187140
Int J Clin Exp Med. 2014 Dec 15;7(12):4975-82
pubmed: 25663995
Trends Pharmacol Sci. 2012 Jan;33(1):3-8
pubmed: 21962460
Antimicrob Agents Chemother. 2002 Aug;46(8):2442-9
pubmed: 12121916
Thorax. 2017 Jan;72(1):1-3
pubmed: 27974631
Chest. 2009 Jun;135(6):1564-1571
pubmed: 19141525
Br J Pharmacol. 2014 Apr;171(7):1783-94
pubmed: 24417187
J Antimicrob Chemother. 2015 Mar;70(3):830-40
pubmed: 25406299
Ann Thorac Surg. 2010 Aug;90(2):419-26
pubmed: 20667323
Chest. 2008 Jul;134(1):20-9
pubmed: 18403658
Chemotherapy. 2003 Jul;49(4):163-6
pubmed: 12886050
Antimicrob Agents Chemother. 1996 Jun;40(6):1366-70
pubmed: 8726002
Antiviral Res. 2017 Aug;144:48-56
pubmed: 28535933
J Immunol. 2013 Aug 15;191(4):1792-9
pubmed: 23833238
Exp Lung Res. 2010 Dec;36(10):602-14
pubmed: 20874225
J Dermatol Sci. 2008 Mar;49(3):195-205
pubmed: 18036782
Lancet. 1967 Aug 12;2(7511):319-23
pubmed: 4143721
Front Cell Infect Microbiol. 2019 Jul 15;9:253
pubmed: 31380296
Respir Res. 2006 Jan 27;7:16
pubmed: 16438734
Digestion. 2009;80(2):65-73
pubmed: 19494493
Circulation. 1999 Jul 27;100(4):400-6
pubmed: 10421601
J Int Med Res. 1996 Jul-Aug;24(4):345-51
pubmed: 8854288
J Antibiot (Tokyo). 2015 Aug;68(8):485-90
pubmed: 25735844
Int J Antimicrob Agents. 2009 Nov;34(5):477-81
pubmed: 19665359
J Immunol. 2019 Aug 15;203(4):1021-1030
pubmed: 31263039
J Med Virol. 2017 Dec;89(12):2239-2243
pubmed: 28792077
Ann Transl Med. 2018 Jan;6(2):24
pubmed: 29430441
Respirology. 2012 Jul;17(5):802-7
pubmed: 22288725
Respir Res. 2013 May 10;14:52
pubmed: 23663489
Am J Respir Crit Care Med. 2016 Oct 15;194(8):961-973
pubmed: 27064380
Drugs. 2011 Apr 16;71(6):757-70
pubmed: 21504252
J Surg Res. 2003 May 15;111(2):185-95
pubmed: 12850461
PLoS One. 2017 Nov 17;12(11):e0187187
pubmed: 29149185
Adv Dent Res. 1998 Nov;12(2):12-26
pubmed: 9972117
Antimicrob Agents Chemother. 2004 May;48(5):1581-5
pubmed: 15105108
Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48
pubmed: 20592239
Respir Res. 2015 Feb 07;16:15
pubmed: 25849726
Antimicrob Agents Chemother. 1990 Jun;34(6):1056-60
pubmed: 2168141
Chemotherapy. 2006;52(3):122-4
pubmed: 16612054
Nat Rev Immunol. 2014 Mar;14(3):166-80
pubmed: 24481336
Pulm Pharmacol Ther. 2007;20(6):669-75
pubmed: 17045828
Int J Nanomedicine. 2016 Dec 14;11:6781-6794
pubmed: 28008253
Pharmacol Res Perspect. 2014 Oct;2(5):e00058
pubmed: 25505605
Chemotherapy. 2012;58(3):206-11
pubmed: 22759803
Antimicrob Agents Chemother. 2002 Oct;46(10):3327-30
pubmed: 12234873
Int Immunopharmacol. 2019 Jul;72:243-251
pubmed: 31003001
Chemotherapy. 1995 Jan-Feb;41(1):45-9
pubmed: 7875021
N Engl J Med. 2017 Aug 10;377(6):562-572
pubmed: 28792873
Thromb Haemost. 2013 Apr;109(4):684-95
pubmed: 23348831
Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L580-7
pubmed: 16698855
J Inflamm (Lond). 2012 Sep 03;9(1):31
pubmed: 22943365
Clin Infect Dis. 2005 Aug 1;41 Suppl 3:S208-12
pubmed: 15983902
Mol Immunol. 2021 Jan;129:39-44
pubmed: 33271353
Shock. 2012 Apr;37(4):424-32
pubmed: 22258231
Lung. 2002;180(2):73-89
pubmed: 12182159
PLoS One. 2015 Jan 30;10(1):e0114574
pubmed: 25635685
PLoS Pathog. 2018 Apr 5;14(4):e1006955
pubmed: 29621339
Annu Rev Pathol. 2011;6:147-63
pubmed: 20936936
Inflamm Res. 2020 Jan;69(1):139-151
pubmed: 31820024
Antimicrob Agents Chemother. 2012 Jul;56(7):3819-25
pubmed: 22564837
Int Immunopharmacol. 2011 Apr;11(4):424-34
pubmed: 21195124
Springerplus. 2016 Jul 28;5(1):1193
pubmed: 27516931
J Pharmacol Exp Ther. 2009 Oct;331(1):104-13
pubmed: 19633061
Respir Res. 2014 Jul 17;15:82
pubmed: 25034539
Crit Care Med. 2011 Aug;39(8):1944-52
pubmed: 21532475
Eur Respir J. 2006 Sep;28(3):486-95
pubmed: 16737992
J Clin Med. 2021 Feb 12;10(4):
pubmed: 33673270
J Immunol. 2013 Apr 15;190(8):4274-82
pubmed: 23487422
Chest. 2017 May;151(5):1069-1080
pubmed: 27884765
Infect Dis Clin North Am. 2004 Sep;18(3):621-49, xi-
pubmed: 15308279
Crit Care Med. 2000 Jan;28(1):1-7
pubmed: 10667491
Intensive Care Med. 2015 Mar;41(3):470-8
pubmed: 25643902
Am J Respir Crit Care Med. 2004 Dec 15;170(12):1331-9
pubmed: 15361366
Int J Clin Exp Pathol. 2014 Oct 15;7(11):7460-8
pubmed: 25550781
J Antimicrob Chemother. 2008 Mar;61(3):554-60
pubmed: 18230686
Chest. 2012 May;141(5):1153-1159
pubmed: 22116799
Front Microbiol. 2017 Jun 23;8:1041
pubmed: 28690590
Am J Respir Crit Care Med. 2021 Jul 1;204(1):53-63
pubmed: 33760701
Oncol Lett. 2017 Nov;14(5):5211-5220
pubmed: 29098024
Arch Med Res. 2006 Jan;37(1):31-5
pubmed: 16314183
N Engl J Med. 2011 Apr 7;364(14):1293-304
pubmed: 21470008
Antimicrob Agents Chemother. 2010 Feb;54(2):757-62
pubmed: 19949056
Pharmacotherapy. 2019 Nov;39(11):1077-1094
pubmed: 31487056
Am J Respir Crit Care Med. 2010 Jun 15;181(12):1294-309
pubmed: 20167850
Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):853-7
pubmed: 9517602
JCI Insight. 2019 Jan 24;4(2):
pubmed: 30674720
Infection. 2005 Dec;33 Suppl 2:55-70
pubmed: 16518713
Immunity. 2014 Feb 20;40(2):274-88
pubmed: 24530056
J Chemother. 2008 Oct;20(5):609-14
pubmed: 19028625
Nat Med. 2015 Jul;21(7):677-87
pubmed: 26121197
Infect Immun. 2006 Dec;74(12):6707-21
pubmed: 16982840
Cell Res. 2002 Mar;12(1):9-18
pubmed: 11942415
Pediatr Pulmonol. 2018 May;53(5):567-574
pubmed: 29405608
J Infect Dis. 2006 Jan 15;193(2):214-22
pubmed: 16362885
Antimicrob Agents Chemother. 2010 Jun;54(6):2437-47
pubmed: 20231397
Antimicrob Agents Chemother. 2012 Apr;56(4):1744-8
pubmed: 22290944
Infect Immun. 2019 Sep 19;87(10):
pubmed: 31383747
Nat Rev Immunol. 2010 Dec;10(12):826-37
pubmed: 21088683
Am J Respir Crit Care Med. 2012 Jun 1;185(11):1225-34
pubmed: 22461369
Int Immunopharmacol. 2014 Jan;18(1):27-34
pubmed: 24239744
J Extra Corpor Technol. 1999 Jun;31(2):67-75
pubmed: 10724645
Front Immunol. 2018 Mar 13;9:302
pubmed: 29593707
J Heart Lung Transplant. 2008 Nov;27(11):1210-6
pubmed: 18971093
Eur Respir J. 2014 Jan;43(1):276-85
pubmed: 23520315
Life Sci. 2021 Aug 15;279:119662
pubmed: 34081989
Nat Rev Dis Primers. 2019 Mar 14;5(1):18
pubmed: 30872586
Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L709-25
pubmed: 24508730
Antimicrob Agents Chemother. 2007 May;51(5):1879-81
pubmed: 17353246
J Surg Res. 2001 Aug;99(2):245-52
pubmed: 11469893
Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L677-L686
pubmed: 28684545
Infect Immun. 2001 Jul;69(7):4590-9
pubmed: 11402003
Sci Rep. 2016 Jan 18;6:19262
pubmed: 26778774
PLoS One. 2013;8(3):e57483
pubmed: 23478252
Respirology. 2008 Jan;13(1):47-52
pubmed: 18197910
Int J Antimicrob Agents. 2018 Jun;51(6):918-924
pubmed: 29501821
J Infect Dis. 2014 Sep 1;210(5):814-23
pubmed: 24620024
Am J Respir Crit Care Med. 2019 Aug 1;200(3):269-270
pubmed: 30986361
Intensive Care Med. 2019 Jul;45(7):1043-1045
pubmed: 30874823
Thorax. 1998 Oct;53(10):815-7
pubmed: 10193364
Infect Drug Resist. 2012;5:87-102
pubmed: 22787406
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8093-8
pubmed: 9223320
Shock. 2005 Oct;24(4):348-56
pubmed: 16205320
Nat Med. 2008 May;14(5):558-64
pubmed: 18438414
J Antimicrob Chemother. 2007 Feb;59(2):219-23
pubmed: 17114176
J Antimicrob Chemother. 2006 Sep;58(3):615-21
pubmed: 16854958
J Anesth. 2012 Oct;26(5):658-63
pubmed: 22639237
Int J Mol Sci. 2017 Dec 29;19(1):
pubmed: 29286292
Inflammation. 2020 Jun;43(3):1035-1043
pubmed: 31955291
PLoS One. 2015 Jun 18;10(6):e0130248
pubmed: 26086073
Crit Care. 2006;10(6):R155
pubmed: 17092345
PLoS One. 2013 Jun 27;8(6):e67994
pubmed: 23826353
Sci Rep. 2015 Jul 08;5:12016
pubmed: 26152605
Antimicrob Agents Chemother. 2013 Aug;57(8):3883-8
pubmed: 23733468