Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 10 2021
06 10 2021
Historique:
received:
24
06
2021
accepted:
13
09
2021
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Several COVID-19 vaccines have shown good efficacy in clinical trials, but there remains uncertainty about the efficacy of vaccines against different variants. Here, we investigate the efficacy of ChAdOx1 nCoV-19 (AZD1222) against symptomatic COVID-19 in a post-hoc exploratory analysis of a Phase 3 randomised trial in Brazil (trial registration ISRCTN89951424). Nose and throat swabs were tested by PCR in symptomatic participants. Sequencing and genotyping of swabs were performed to determine the lineages of SARS-CoV-2 circulating during the study. Protection against any symptomatic COVID-19 caused by the Zeta (P.2) variant was assessed in 153 cases with vaccine efficacy (VE) of 69% (95% CI 55, 78). 49 cases of B.1.1.28 occurred and VE was 73% (46, 86). The Gamma (P.1) variant arose later in the trial and fewer cases (N = 18) were available for analysis. VE was 64% (-2, 87). ChAdOx1 nCoV-19 provided 95% protection (95% CI 61%, 99%) against hospitalisation due to COVID-19. In summary, we report that ChAdOx1 nCoV-19 protects against emerging variants in Brazil despite the presence of the spike protein mutation E484K.
Identifiants
pubmed: 34615860
doi: 10.1038/s41467-021-25982-w
pii: 10.1038/s41467-021-25982-w
pmc: PMC8494913
doi:
Substances chimiques
COVID-19 Vaccines
0
ChAdOx1 nCoV-19
B5S3K2V0G8
Types de publication
Clinical Trial, Phase III
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5861Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19055
Pays : United Kingdom
Investigateurs
David Buck
(D)
Angie Green
(A)
George MacIntyre-Cockett
(G)
Paolo Piazza
(P)
John A Todd
(JA)
Amy Trebes
(A)
Laura Thomson
(L)
Lygia Accioly Tinoco
(LA)
Karla Cristina Marques Afonso Ferreira
(KCMA)
Cenusa Almeida
(C)
Brian Angus
(B)
Beatriz Arns
(B)
Laiana Arruda
(L)
Renato De Ávila Kfouri
(R)
Lucas Henrique Azevedo da Silva
(LHA)
Matheus José Barbosa Moreira
(MJB)
Brenda Vasconcelos Barbosa Paiva
(BVB)
Louise Bates
(L)
Nancy Bellei
(N)
Bruno Boettger
(B)
Leandro Bonecker Lora
(LB)
Nina Amanda Borges de Araújo
(NAB)
Chrystiane do Nascimento Brito de Oliveira
(CDNB)
Charlie Brown-O'Sullivan
(C)
Daniel Calich Luz
(DC)
Joao Renato Cardoso Mourão
(JRC)
Caroline Scherer Carvalho
(CS)
Paola Cicconi
(P)
Ana Gibertoni Cruz
(AG)
Debora Cunha
(D)
Daniel Marinho Da Costa
(DM)
Isabela Garrido Da Silva Gonzalez
(IG)
Priscila de Arruda Trindade
(P)
Bruno Solano de Freitas Souza
(BS)
Sergio Carlos Assis De Jesus Junior
(SCA)
Maria Isabel de Moraes Pinto
(MI)
Karolyne Porto De Mores
(KP)
Maristela Miyamoto de Nobrega
(MM)
Milla Dias Sampaio
(MD)
Janaína Keyla Dionísio Dos Santos
(JKD)
Alexander D Douglas
(AD)
Suzete Nascimento Farias da Guarda
(SNF)
Mujtaba Ghulam Farooq
(MG)
Shuo Feng
(S)
Marcel Catão Ferreira Dos Santos
(MCF)
Marília Miranda Franco
(MM)
Marianne Garcia de Oliveira
(MG)
Fernanda Garcia Spina
(FG)
Tannyth Gomes Dos Santos
(TG)
Alvaro Henrique Goyanna
(AH)
Rosana Esteves Haddad
(RE)
Adrian V S Hill
(AVS)
Mimi M Hou
(MM)
Bruna Junqueira
(B)
Bruna Somavilla Kelling
(BS)
Baktash Khozoee
(B)
Renan Gustavo Kunst
(RG)
Jonathan Kwok
(J)
Meera Madhavan
(M)
José Antônio Mainardi de Carvalho
(JAM)
Olga Mazur
(O)
Angela M Minassian
(AM)
Leonardo Motta Ramos
(LM)
Celia Hatsuko Myasaki
(CH)
Helena Carolina Noal
(HC)
Natália Nóbrega de Lima
(NN)
Rabiullah Noristani
(R)
Ana Luiza Perez
(AL)
Daniel J Phillips
(DJ)
Priscila Pinheiro
(P)
Jéssica Morgana Gediel Pinheiro
(JMG)
Marie Marcelle Prestes Camara
(MMP)
Isabella Queiroz
(I)
Alessandra Ramos Souza
(AR)
Thais Regina Y Castro
(TRY)
Hannah Robinson
(H)
Marianna Rocha Jorge
(MR)
Talita Rochetti
(T)
Mariana Bernadi S Saba
(MBS)
Natalia Zerbinatti Salvador
(NZ)
Fernanda Caldeira Veloso Santos
(FCV)
Mayara Fraga Santos Guerra
(MFS)
Samiullah Seddiqi
(S)
Roberta Senger
(R)
Robert Shaw
(R)
Airanuedida Silva Soares
(AS)
Rinn Song
(R)
Guilherme G Sorio
(GG)
Ricardo Stein
(R)
Arabella V S Stuart
(AVS)
Tais Tasqueto Tassinari
(TT)
Cheryl Turner
(C)
Tarsila Vieceli
(T)
Taiane A Vieira
(TA)
João Gabriel Villar Cavalcanti
(JGV)
Marion E E Watson
(MEE)
Andy Yao
(A)
Rafael Zimmer
(R)
Informations de copyright
© 2021. The Author(s).
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