Metabolic modulation of tumours with engineered bacteria for immunotherapy.
Adoptive Transfer
Animals
Arginine
/ metabolism
B7-H1 Antigen
/ antagonists & inhibitors
Cell Line, Tumor
Escherichia coli
Female
Immunotherapy
/ methods
Lymphocytes, Tumor-Infiltrating
/ immunology
Metabolic Engineering
Mice
Mice, Inbred C57BL
Mice, Knockout
Microorganisms, Genetically-Modified
Neoplasms, Experimental
/ metabolism
Probiotics
Proteome
Synthetic Biology
T-Lymphocytes
/ immunology
Tumor Microenvironment
/ immunology
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
16
05
2019
accepted:
07
09
2021
pubmed:
8
10
2021
medline:
9
2
2022
entrez:
7
10
2021
Statut:
ppublish
Résumé
The availability of L-arginine in tumours is a key determinant of an efficient anti-tumour T cell response
Identifiants
pubmed: 34616044
doi: 10.1038/s41586-021-04003-2
pii: 10.1038/s41586-021-04003-2
doi:
Substances chimiques
B7-H1 Antigen
0
Proteome
0
Arginine
94ZLA3W45F
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
662-666Subventions
Organisme : European Research Council
Pays : International
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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