A multimodal cell census and atlas of the mammalian primary motor cortex.
Animals
Atlases as Topic
Callithrix
Epigenomics
Female
Gene Expression Profiling
Glutamates
/ metabolism
Humans
In Situ Hybridization, Fluorescence
Male
Mice
Motor Cortex
/ anatomy & histology
Neurons
/ classification
Organ Specificity
Phylogeny
Single-Cell Analysis
Species Specificity
Transcriptome
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
04
10
2020
accepted:
25
08
2021
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
3
11
2021
Statut:
ppublish
Résumé
Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization
Identifiants
pubmed: 34616075
doi: 10.1038/s41586-021-03950-0
pii: 10.1038/s41586-021-03950-0
pmc: PMC8494634
doi:
Substances chimiques
Glutamates
0
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-102Subventions
Organisme : NIMH NIH HHS
ID : U19 MH114821
Pays : United States
Organisme : NIMH NIH HHS
ID : R24 MH114815
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH117072
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH117079
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY023173
Pays : United States
Organisme : NINDS NIH HHS
ID : R33 NS115183
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH121260
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114828
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS086082
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094360
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114829
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114824
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114812
Pays : United States
Organisme : NIH HHS
ID : P51 OD010425
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH120404
Pays : United States
Organisme : NIMH NIH HHS
ID : R24 MH114793
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114825
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG073205
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066509
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH123199
Pays : United States
Organisme : NIH HHS
ID : S10 OD023689
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114819
Pays : United States
Organisme : NIH HHS
ID : OD010425
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH105982
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC019370
Pays : United States
Organisme : NIMH NIH HHS
ID : U24 MH114827
Pays : United States
Organisme : NIMH NIH HHS
ID : R24 MH117295
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH122169
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH121282
Pays : United States
Organisme : NINDS NIH HHS
ID : R61 NS115183
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH114831
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH117023
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000423
Pays : United States
Organisme : NIMH NIH HHS
ID : R24 MH114788
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS039600
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110767
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH114830
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH114126
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH116990
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014195
Pays : United States
Investigateurs
Edward M Callaway
(EM)
Hong-Wei Dong
(HW)
Joseph R Ecker
(JR)
Michael J Hawrylycz
(MJ)
Z Josh Huang
(ZJ)
Ed S Lein
(ES)
John Ngai
(J)
Pavel Osten
(P)
Bing Ren
(B)
Andreas Savas Tolias
(AS)
Owen White
(O)
Hongkui Zeng
(H)
Xiaowei Zhuang
(X)
Giorgio A Ascoli
(GA)
M Margarita Behrens
(MM)
Jerold Chun
(J)
Guoping Feng
(G)
James C Gee
(JC)
Satrajit S Ghosh
(SS)
Yaroslav O Halchenko
(YO)
Ronna Hertzano
(R)
Byung Kook Lim
(BK)
Maryann E Martone
(ME)
Lydia Ng
(L)
Lior Pachter
(L)
Alexander J Ropelewski
(AJ)
Timothy L Tickle
(TL)
X William Yang
(XW)
Kun Zhang
(K)
Trygve E Bakken
(TE)
Philipp Berens
(P)
Tanya L Daigle
(TL)
Julie A Harris
(JA)
Nikolas L Jorstad
(NL)
Brian E Kalmbach
(BE)
Dmitry Kobak
(D)
Yang Eric Li
(YE)
Hanqing Liu
(H)
Katherine S Matho
(KS)
Eran A Mukamel
(EA)
Maitham Naeemi
(M)
Federico Scala
(F)
Pengcheng Tan
(P)
Jonathan T Ting
(JT)
Fangming Xie
(F)
Meng Zhang
(M)
Zhuzhu Zhang
(Z)
Jingtian Zhou
(J)
Brian Zingg
(B)
Ethan Armand
(E)
Zizhen Yao
(Z)
Darren Bertagnolli
(D)
Tamara Casper
(T)
Kirsten Crichton
(K)
Nick Dee
(N)
Dinh Diep
(D)
Song-Lin Ding
(SL)
Weixiu Dong
(W)
Elizabeth L Dougherty
(EL)
Olivia Fong
(O)
Melissa Goldman
(M)
Jeff Goldy
(J)
Rebecca D Hodge
(RD)
Lijuan Hu
(L)
C Dirk Keene
(CD)
Fenna M Krienen
(FM)
Matthew Kroll
(M)
Blue B Lake
(BB)
Kanan Lathia
(K)
Sten Linnarsson
(S)
Christine S Liu
(CS)
Evan Z Macosko
(EZ)
Steven A McCarroll
(SA)
Delissa McMillen
(D)
Naeem M Nadaf
(NM)
Thuc Nghi Nguyen
(TN)
Carter R Palmer
(CR)
Thanh Pham
(T)
Nongluk Plongthongkum
(N)
Nora M Reed
(NM)
Aviv Regev
(A)
Christine Rimorin
(C)
William J Romanow
(WJ)
Steven Savoia
(S)
Kimberly Siletti
(K)
Kimberly Smith
(K)
Josef Sulc
(J)
Bosiljka Tasic
(B)
Michael Tieu
(M)
Amy Torkelson
(A)
Herman Tung
(H)
Cindy T J van Velthoven
(CTJ)
Charles R Vanderburg
(CR)
Anna Marie Yanny
(AM)
Rongxin Fang
(R)
Xiaomeng Hou
(X)
Jacinta D Lucero
(JD)
Julia K Osteen
(JK)
Antonio Pinto-Duarte
(A)
Olivier Poirion
(O)
Sebastian Preissl
(S)
Xinxin Wang
(X)
Andrew I Aldridge
(AI)
Anna Bartlett
(A)
Lara Boggeman
(L)
Carolyn O'Connor
(C)
Rosa G Castanon
(RG)
Huaming Chen
(H)
Conor Fitzpatrick
(C)
Chongyuan Luo
(C)
Joseph R Nery
(JR)
Michael Nunn
(M)
Angeline C Rivkin
(AC)
Wei Tian
(W)
Bertha Dominguez
(B)
Tony Ito-Cole
(T)
Matthew Jacobs
(M)
Xin Jin
(X)
Cheng-Ta Lee
(CT)
Kuo-Fen Lee
(KF)
Paula Assakura Miyazaki
(PA)
Yan Pang
(Y)
Mohammad Rashid
(M)
Jared B Smith
(JB)
Minh Vu
(M)
Elora Williams
(E)
Tommaso Biancalani
(T)
A Sina Booeshaghi
(AS)
Megan Crow
(M)
Sandrine Dudoit
(S)
Stephan Fischer
(S)
Jesse Gillis
(J)
Qiwen Hu
(Q)
Peter V Kharchenko
(PV)
Sheng-Yong Niu
(SY)
Vasilis Ntranos
(V)
Elizabeth Purdom
(E)
Davide Risso
(D)
Hector Roux de Bézieux
(HR)
Saroja Somasundaram
(S)
Kelly Street
(K)
Valentine Svensson
(V)
Eeshit Dhaval Vaishnav
(ED)
Koen Van den Berge
(K)
Joshua D Welch
(JD)
Xu An
(X)
Helen S Bateup
(HS)
Ian Bowman
(I)
Rebecca K Chance
(RK)
Nicholas N Foster
(NN)
William Galbavy
(W)
Hui Gong
(H)
Lin Gou
(L)
Joshua T Hatfield
(JT)
Houri Hintiryan
(H)
Karla E Hirokawa
(KE)
Gukhan Kim
(G)
Daniel J Kramer
(DJ)
Anan Li
(A)
Xiangning Li
(X)
Qingming Luo
(Q)
Rodrigo Muñoz-Castañeda
(R)
David A Stafford
(DA)
Zhao Feng
(Z)
Xueyan Jia
(X)
Shengdian Jiang
(S)
Tao Jiang
(T)
Xiuli Kuang
(X)
Rachael Larsen
(R)
Phil Lesnar
(P)
Yaoyao Li
(Y)
Yuanyuan Li
(Y)
Lijuan Liu
(L)
Hanchuan Peng
(H)
Lei Qu
(L)
Miao Ren
(M)
Zongcai Ruan
(Z)
Elise Shen
(E)
Yuanyuan Song
(Y)
Wayne Wakeman
(W)
Peng Wang
(P)
Yimin Wang
(Y)
Yun Wang
(Y)
Lulu Yin
(L)
Jing Yuan
(J)
Sujun Zhao
(S)
Xuan Zhao
(X)
Arun Narasimhan
(A)
Ramesh Palaniswamy
(R)
Samik Banerjee
(S)
Liya Ding
(L)
Dhananjay Huilgol
(D)
Bingxing Huo
(B)
Hsien-Chi Kuo
(HC)
Sophie Laturnus
(S)
Xu Li
(X)
Partha P Mitra
(PP)
Judith Mizrachi
(J)
Quanxin Wang
(Q)
Peng Xie
(P)
Feng Xiong
(F)
Yang Yu
(Y)
Stephen W Eichhorn
(SW)
Jim Berg
(J)
Matteo Bernabucci
(M)
Yves Bernaerts
(Y)
Cathryn René Cadwell
(CR)
Jesus Ramon Castro
(JR)
Rachel Dalley
(R)
Leonard Hartmanis
(L)
Gregory D Horwitz
(GD)
Xiaolong Jiang
(X)
Andrew L Ko
(AL)
Elanine Miranda
(E)
Shalaka Mulherkar
(S)
Philip R Nicovich
(PR)
Scott F Owen
(SF)
Rickard Sandberg
(R)
Staci A Sorensen
(SA)
Zheng Huan Tan
(ZH)
Shona Allen
(S)
Dirk Hockemeyer
(D)
Angus Y Lee
(AY)
Matthew B Veldman
(MB)
Ricky S Adkins
(RS)
Seth A Ament
(SA)
Héctor Corrada Bravo
(HC)
Robert Carter
(R)
Apaala Chatterjee
(A)
Carlo Colantuoni
(C)
Jonathan Crabtree
(J)
Heather Creasy
(H)
Victor Felix
(V)
Michelle Giglio
(M)
Brian R Herb
(BR)
Jayaram Kancherla
(J)
Anup Mahurkar
(A)
Carrie McCracken
(C)
Lance Nickel
(L)
Dustin Olley
(D)
Joshua Orvis
(J)
Michael Schor
(M)
Greg Hood
(G)
Benjamin Dichter
(B)
Michael Grauer
(M)
Brian Helba
(B)
Anita Bandrowski
(A)
Nikolaos Barkas
(N)
Benjamin Carlin
(B)
Florence D D'Orazi
(FD)
Kylee Degatano
(K)
Thomas H Gillespie
(TH)
Farzaneh Khajouei
(F)
Kishori Konwar
(K)
Carol Thompson
(C)
Kathleen Kelly
(K)
Stephanie Mok
(S)
Susan Sunkin
(S)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. The Author(s).
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