Presence or severity of Hashimoto's thyroiditis does not influence basal calcitonin levels: observations from CROHT biobank.
Adult
Age Factors
Autoantibodies
/ blood
Biological Specimen Banks
Biological Variation, Population
Calcitonin
/ biosynthesis
Croatia
/ epidemiology
Female
Hashimoto Disease
/ blood
Hormone Replacement Therapy
/ methods
Humans
Male
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Factors
Thyroid Hormones
/ immunology
Thyroxine
/ therapeutic use
Age
BSA
Calcitonin
Hashimoto’s thyroiditis
Thyroglobulin antibody (TgAb)
Thyroid autoimmunity
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
08
06
2021
accepted:
26
09
2021
pubmed:
8
10
2021
medline:
24
3
2022
entrez:
7
10
2021
Statut:
ppublish
Résumé
The influence of Hashimoto's thyroiditis (HT) on calcitonin (Ct) production is unresolved question. The aim of this study was to explore if basal Ct levels are influenced by the presence/severity of HT or correlated with clinical phenotypes of HT patients. We included 467 HT patients and 184 control participants, from Croatian Biobank of HT patients (CROHT), in this retrospective study. Calcitonin levels between HT patients and controls were compared using Mann-Whitney test. Ct levels between two subgroups of HT patients, divided by intake of levothyroxine (LT4) therapy, were additionally tested to take into account the illness severity. Spearman rank correlation test was used to analyze correlations between Ct levels and 14 relevant phenotypes. We have not detected significant differences in median Ct levels between HT patients and controls (2.2 vs 2.35 pg/mL, respectively, P = 0.717) nor in-between two subgroups of HT patients (P = 0.347). We have not detected statistically significant correlations between Ct levels and clinical phenotypes, although we identified three weak nominal correlations: negative correlation of Ct with TgAb in all HT patients (r = - 0.1, P = 0.04); negative correlation of Ct with age in subgroup of HT patients without LT4 therapy (r = - 0.13, P = 0.04); positive correlation of Ct with BSA in subgroup of HT patients on LT4 therapy (r = 0.16, P = 0.042). Our results suggest that HT patients of all disease stages preserve Ct production as healthy individuals and there is no need for Ct measurements in the absence of a nodule. Additional confirmation and clarification of observed nominal correlations are needed due to potential clinical relevance of TgAb and age-dependent Ct decrease in HT women.
Identifiants
pubmed: 34617251
doi: 10.1007/s40618-021-01685-3
pii: 10.1007/s40618-021-01685-3
doi:
Substances chimiques
Autoantibodies
0
Thyroid Hormones
0
Calcitonin
9007-12-9
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
597-605Subventions
Organisme : Hrvatska Zaklada za Znanost
ID : 4950
Informations de copyright
© 2021. Italian Society of Endocrinology (SIE).
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