Defining Baseline Mechanisms of Cefiderocol Resistance in the Enterobacterales.
carbapenem-resistant Enterobacterales
cefiderocol
mechanisms of resistance
Journal
Microbial drug resistance (Larchmont, N.Y.)
ISSN: 1931-8448
Titre abrégé: Microb Drug Resist
Pays: United States
ID NLM: 9508567
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
pubmed:
8
10
2021
medline:
1
3
2022
entrez:
7
10
2021
Statut:
ppublish
Résumé
The objective of this study was to identify putative mechanisms contributing to baseline cefiderocol resistance among carbapenem-resistant Enterobacterales (CRE). We evaluated 56 clinical CRE isolates with no previous exposure to cefiderocol. Cefiderocol and comparator agent minimum inhibitory concentrations (MICs) were determined by broth microdilution. Short-read and/or long-read whole genome sequencing was pursued. Cefiderocol nonwild type (NWT;
Identifiants
pubmed: 34619049
doi: 10.1089/mdr.2021.0095
pmc: PMC8885434
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cephalosporins
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-170Subventions
Organisme : NIAID NIH HHS
ID : R21 AI153580
Pays : United States
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