ATP-citrate lyase promotes axonal transport across species.

ATP Citrate (pro-S)-Lyase / genetics Acetyl Coenzyme A / metabolism Acetylation Acetyltransferases / genetics Animals Axonal Transport / genetics Drosophila melanogaster Dysautonomia, Familial / metabolism Female Fibroblasts / metabolism Humans Larva Male Mice Microtubules / metabolism Protein Processing, Post-Translational Tubulin / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
07 10 2021
Historique:
received: 03 08 2020
accepted: 24 08 2021
entrez: 8 10 2021
pubmed: 9 10 2021
medline: 3 11 2021
Statut: epublish

Résumé

Microtubule (MT)-based transport is an evolutionary conserved process finely tuned by posttranslational modifications. Among them, α-tubulin acetylation, primarily catalyzed by a vesicular pool of α-tubulin N-acetyltransferase 1 (Atat1), promotes the recruitment and processivity of molecular motors along MT tracks. However, the mechanism that controls Atat1 activity remains poorly understood. Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide Acetyl-Coenzyme-A (Acetyl-CoA) to Atat1. In addition, we showed that Acly expression is reduced upon loss of Elongator activity, further connecting Elongator to Atat1 in a pathway regulating α-tubulin acetylation and MT-dependent transport in projection neurons, across species. Remarkably, comparable defects occur in fibroblasts from Familial Dysautonomia (FD) patients bearing an autosomal recessive mutation in the gene coding for the Elongator subunit ELP1. Our data may thus shine light on the pathophysiological mechanisms underlying FD.

Identifiants

DOI: 10.1038/s41467-021-25786-y PMID: 34620845 PMC: PMC8497606
pubmed: 34620845
doi: 10.1038/s41467-021-25786-y
pii: 10.1038/s41467-021-25786-y
pmc: PMC8497606
doi:

Substances chimiques

Tubulin 0
Acetyl Coenzyme A 72-89-9
Acetyltransferases EC 2.3.1.-
ATP Citrate (pro-S)-Lyase EC 2.3.3.8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5878

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2021. The Author(s).

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Auteurs

Aviel Even (A)

Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Ramat Aviv, 69978, Israel.
ORCID: 0000-0003-0534-4462

Giovanni Morelli (G)

Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium.
BIOMED Research Institute, Hasselt, 3500, Belgium.

Silvia Turchetto (S)

Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium.

Michal Shilian (M)

Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Ramat Aviv, 69978, Israel.

Romain Le Bail (RL)

Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium.

Sophie Laguesse (S)

Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium.

Nathalie Krusy (N)

Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium.

Ariel Brisker (A)

Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Ramat Aviv, 69978, Israel.

Alexander Brandis (A)

Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.

Shani Inbar (S)

Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Ramat Aviv, 69978, Israel.

Alain Chariot (A)

Laboratory of Medical Chemistry, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium.

Frédéric Saudou (F)

Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000, Grenoble, France.
Inserm, U1216, F-38000, Grenoble, France.
CHU Grenoble Alpes, F-38000, Grenoble, France.
ORCID: 0000-0001-6107-1046

Paula Dietrich (P)

Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Ioannis Dragatsis (I)

Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Bert Brone (B)

BIOMED Research Institute, Hasselt, 3500, Belgium.
ORCID: 0000-0002-4851-9480

Loïc Broix (L)

Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium.
ORCID: 0000-0002-8231-370X

Jean-Michel Rigo (JM)

BIOMED Research Institute, Hasselt, 3500, Belgium.
ORCID: 0000-0002-0031-526X

Miguel Weil (M)

Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Ramat Aviv, 69978, Israel. miguelw@tauex.tau.ac.il.

Laurent Nguyen (L)

Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium. lnguyen@uliege.be.
ORCID: 0000-0002-8560-3008

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › ATP citrate (pro-S)-lyase › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Acyl coenzyme A › Acétyl coenzyme A › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Métabolisme › Acylation › Acétylation › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acetyltransferases › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Eucaryotes › Animaux › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transport axonal › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies neurodégénératives héréditaires › Neuropathies héréditaires sensitives et autonomes › Dysautonomie familiale › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Larve › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Microtubules › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › ATP-citrate lyase promotes axonal transport...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › ATP-citrate lyase promotes axonal transport...