Targeting Histamine and Histamine Receptors for the Precise Regulation of Feeding.

Brain / physiology Circadian Rhythm / physiology Feeding Behavior / physiology Histamine / physiology Receptors, Histamine / metabolism
Feeding behaviors Feeding circadian rhythm Feeding motivation Histamine Histamine receptors Satiety Taste perception

Journal

Current topics in behavioral neurosciences
ISSN: 1866-3370
Titre abrégé: Curr Top Behav Neurosci
Pays: Germany
ID NLM: 101535383

Informations de publication

Date de publication:
2022
Historique:
pubmed: 9 10 2021
medline: 1 10 2022
entrez: 8 10 2021
Statut: ppublish

Résumé

Histamine has long been accepted as an anorexigenic agent. However, lines of evidence have suggested that the roles of histamine in feeding behaviors are much more complex than previously thought, being involved in satiety, satiation, feeding motivation, feeding circadian rhythm, and taste perception and memory. The functional diversity of histamine makes it a viable target for clinical management of obesity and other feeding-related disorders. Here, we update the current knowledge about the functions of histamine in feeding and summarize the underlying molecular and neural circuit mechanisms. Finally, we review the main clinical studies about the impacts of histamine-related compounds on weight control and discuss insights into future research on the roles of histamine in feeding. Despite the recent progress in histamine research, the histaminergic feeding circuits are poorly understood, and it is also worth verifying the functions of histamine receptors in a more spatiotemporally specific manner.

Identifiants

DOI: 10.1007/7854_2021_258 PMID: 34622397
pubmed: 34622397
doi: 10.1007/7854_2021_258
doi:

Substances chimiques

Receptors, Histamine 0
Histamine 820484N8I3

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

355-387

Informations de copyright

© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.

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Auteurs

Yanrong Zheng (Y)

Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

Zhong Chen (Z)

Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. chenzhong@zju.edu.cn.

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