Normal cognition in Parkinson's disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [
Acetylcholine
Cognition
FEOBV
Mild cognitive impairment
PET imaging
Journal
Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
28
04
2021
revised:
21
09
2021
accepted:
22
09
2021
pubmed:
11
10
2021
medline:
9
2
2022
entrez:
10
10
2021
Statut:
ppublish
Résumé
Severe cholinergic degeneration is known to occur in Parkinson's disease (PD) and is thought to play a primary role in the cognitive decline associated with this disease. Although cholinergic losses occur in all patients with PD, cognitive performance remains normal for many of them, suggesting compensatory mechanisms in those. This exploratory study aimed at verifying if normal cognition in PD may involve distinctive features of the brain cholinergic systems. Following extensive neuropsychological screening in 25 patients with PD, 12 were selected and evenly distributed between a cognitively normal (PD-CN) group, and a mild cognitive impairment (PD-MCI) group. Each group was compared with matched healthy volunteers (HV) on standardized cognitive scales (MoCA, PDCRS), and PET imaging with [ [ These findings suggest a compensatory upregulation of the hippocampal cholinergic innervation in PD-CN, which might underly normal cognitive performances in spite of cortical cholinergic denervation in other regions.
Sections du résumé
BACKGROUND
Severe cholinergic degeneration is known to occur in Parkinson's disease (PD) and is thought to play a primary role in the cognitive decline associated with this disease. Although cholinergic losses occur in all patients with PD, cognitive performance remains normal for many of them, suggesting compensatory mechanisms in those.
OBJECTIVES
This exploratory study aimed at verifying if normal cognition in PD may involve distinctive features of the brain cholinergic systems.
METHODS
Following extensive neuropsychological screening in 25 patients with PD, 12 were selected and evenly distributed between a cognitively normal (PD-CN) group, and a mild cognitive impairment (PD-MCI) group. Each group was compared with matched healthy volunteers (HV) on standardized cognitive scales (MoCA, PDCRS), and PET imaging with [
RESULTS
[
CONCLUSION
These findings suggest a compensatory upregulation of the hippocampal cholinergic innervation in PD-CN, which might underly normal cognitive performances in spite of cortical cholinergic denervation in other regions.
Identifiants
pubmed: 34628195
pii: S1353-8020(21)00347-3
doi: 10.1016/j.parkreldis.2021.09.018
pii:
doi:
Substances chimiques
Cholinergic Agents
0
Piperidines
0
Radioactive Tracers
0
fluoroethoxy-benzovesamicol
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-166Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.