[Renal carcinoma with leiomyomatous stroma and osseous metaplasia from a patient diagnosed with a tuberous sclerosis complex].
Carcinome rénal à stroma léiomyomateux avec métaplasie osseuse chez un patient porteur d’une sclérose tubéreuse de Bourneville.
Carcinome à cellules rénales
Leiomyomatous stroma
Mutation TSC2
Métaplasie osseuse
Osseous metaplasia
Renal cell carcinoma
Sclérose tubéreuse
Stroma léiomyomateux
TSC2 gene mutation
Tuberous sclerosis
Journal
Annales de pathologie
ISSN: 0242-6498
Titre abrégé: Ann Pathol
Pays: France
ID NLM: 8106337
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
17
12
2018
revised:
22
01
2021
accepted:
14
06
2021
pubmed:
12
10
2021
medline:
16
11
2021
entrez:
11
10
2021
Statut:
ppublish
Résumé
Renal cell carcinoma with leiomyomatous stroma is a rare and poorly described histopathological entity. Here we report a unique case with osseous metaplasia, in a 31-year-old man recently diagnosed with a tuberous sclerosis complex (TSC2 gene mutation). Partial nephrectomy was performed. Histologically, the epithelial component was made up of papillary and alveolar structures with clear to eosinophilic cytoplasm, and basally located nuclei. The cells are surrounded by an abundant smooth muscle stroma with focally osseous metaplasia. The tumor was positive for carbonic anhydrase IX, cytokeratin 7, cytokeratin 20, and CD10, and negative for TFE3. This emerging entity is highly correlated to tuberous sclerosis complex, which justifies a screening for the syndrome when this diagnosis is made.
Identifiants
pubmed: 34629215
pii: S0242-6498(21)00166-8
doi: 10.1016/j.annpat.2021.06.005
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Case Reports
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
557-560Informations de copyright
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