Transplacental transfer of RSV antibody in Australian First Nations infants.
RSV antibody
indigenous infants
transplacental transfer
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
15
09
2021
received:
23
06
2021
accepted:
08
10
2021
pubmed:
12
10
2021
medline:
9
2
2022
entrez:
11
10
2021
Statut:
ppublish
Résumé
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infection hospitalisations in Aboriginal infants specifically those aged <6 months. Maternally derived RSV antibody (Ab) can protect against severe RSV disease in infancy. However, the efficiency of transplacental transfer of maternal anti-RSV Ab remains unknown in Aboriginal infants. We characterised RSV Ab in Australian First Nations mother-infant pairs (n = 78). We investigated impact of covariates including low birthweight, gestational age (GA), sex of the baby, maternal age and multiparity of the mother on cord to maternal anti-RSV Ab titre ratio (CMTR) using multivariable logistic regression model. All (n = 78) but one infant was born full term (median GA: 39 weeks, interquartile range: 38-40 weeks) and 56% were males. The mean log
Identifiants
pubmed: 34633091
doi: 10.1002/jmv.27383
pmc: PMC7613379
mid: EMS152544
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
782-786Subventions
Organisme : Wellcome Trust
ID : 203077
Pays : United Kingdom
Informations de copyright
© 2021 Wiley Periodicals LLC.
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