Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle.
Adaptor Proteins, Signal Transducing
/ metabolism
Animals
Caveolae
/ metabolism
Cell Line
Embryo, Nonmammalian
/ metabolism
Imaging, Three-Dimensional
Membrane Proteins
/ metabolism
Mice, Inbred C57BL
Muscle Fibers, Skeletal
/ metabolism
Muscle Proteins
/ metabolism
Muscle, Skeletal
/ metabolism
Nerve Tissue Proteins
/ metabolism
Protein Binding
Sarcolemma
/ metabolism
Tumor Suppressor Proteins
/ metabolism
Zebrafish
/ embryology
Zebrafish Proteins
/ metabolism
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
06 12 2021
06 12 2021
Historique:
received:
09
05
2019
revised:
02
06
2021
accepted:
20
09
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
24
12
2021
Statut:
ppublish
Résumé
The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by analyzing two vertebrate systems, mouse and zebrafish. In both models, Cavin4 localized to T-tubules, and loss of Cavin4 resulted in aberrant T-tubule maturation. In zebrafish, which possess duplicated cavin4 paralogs, Cavin4b was shown to directly interact with the T-tubule-associated BAR domain protein Bin1. Loss of both Cavin4a and Cavin4b caused aberrant accumulation of interconnected caveolae within the T-tubules, a fragmented T-tubule network enriched in Caveolin-3, and an impaired Ca2+ response upon mechanical stimulation. We propose a role for Cavin4 in remodeling the T-tubule membrane early in development by recycling caveolar components from the T-tubule to the sarcolemma. This generates a stable T-tubule domain lacking caveolae that is essential for T-tubule function.
Identifiants
pubmed: 34633413
pii: 212693
doi: 10.1083/jcb.201905065
pmc: PMC8513623
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Bin1 protein, mouse
0
Cavin4 protein, mouse
0
Membrane Proteins
0
Muscle Proteins
0
Nerve Tissue Proteins
0
Tumor Suppressor Proteins
0
Zebrafish Proteins
0
bin1b protein, zebrafish
0
cavin4b protein, zebrafish
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021 Lo et al.
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